Macedonian First League
1.MFL 
Relegated: FK Sileks**, FK Vardar, FK Belasica.
Qualification for the Champions League first qualifying round : FK Škendija
Qualification for the Europa Conference League first qualifying round : KF Shkupi, FC Struga Trim-Lum, FK Sileks*.
* Sileks qualified for the Europa Conference League first qualifying round by winning the 2020–21 Macedonian Football Cup.
** At the end of the season, the second placed teams of the two group (East and West, GFK Tikvesh and FK Ohrid) in the Macedonian Second League will be played a play-off with the 9 and 1oth placed team (FK Sileks and KF Renova) in the Macedonian First League.
Clasificación
Liga | Pts | PJ | G | E | P | GA | GE | GA-GE |
| Shkendija | 75 | 33 | 22 | 9 | 2 | 69 | 26 | 43 |
| Shkupi | 59 | 33 | 16 | 11 | 6 | 41 | 24 | 17 |
| FC Struga | 57 | 33 | 15 | 12 | 6 | 39 | 24 | 15 |
| Makdonija | 55 | 33 | 16 | 7 | 10 | 53 | 43 | 10 |
| Rabtnicki | 48 | 33 | 11 | 15 | 7 | 45 | 39 | 6 |
| Pelister | 45 | 33 | 12 | 9 | 12 | 34 | 38 | -4 |
| Akademija | 41 | 33 | 12 | 5 | 16 | 32 | 36 | -4 |
| FK Borec | 40 | 33 | 11 | 7 | 15 | 32 | 36 | -4 |
| Sileks | 36 | 33 | 10 | 6 | 17 | 49 | 45 | 4 |
| Renova | 36 | 33 | 8 | 12 | 13 | 36 | 46 | -10 |
| Vardar | 31 | 33 | 7 | 10 | 16 | 32 | 60 | -28 |
| Belasica | 17 | 33 | 4 | 5 | 24 | 23 | 68 | -45 |