Fortuna:Liga
1. Liga 
Relegated: FC Zbrojovka Brno, 1. FK Příbram, SFC Opava.
Qualification for the Champions League Third qualifying round: Slavia Praha.
Qualification for the Champions League Second qualifying round: Sparta Praha.
Qualification for the Europa League third qualifying round: FK Jablonec*.
Qualification for the Europa Conference League second qualifying round: 1. FC Slovácko, FC Viktoria Plzeň.
* The Europa League qualifying spot go to the third place team as 2020–21 Czech Cup winner Slavia Prague qualified for Champions League.
Fortuna:Liga Fortuna:Liga Clasificación
Equipo | PJ | Pts | G | E | P | GA | GE | GA-GE | |
| 1 | Slavia | 34 | 86 | 26 | 8 | 0 | 85 | 20 | 65 |
| 2 | Sparta | 34 | 74 | 23 | 5 | 6 | 82 | 43 | 39 |
| 3 | Jablonec | 34 | 69 | 21 | 6 | 7 | 59 | 33 | 26 |
| 4 | Slovácko | 34 | 63 | 19 | 6 | 9 | 58 | 33 | 25 |
| 5 | V.Plzeň | 34 | 58 | 17 | 7 | 10 | 60 | 45 | 15 |
| 6 | Liberec | 34 | 52 | 14 | 10 | 10 | 44 | 32 | 12 |
| 7 | Pardubice | 34 | 52 | 15 | 7 | 12 | 41 | 42 | -1 |
| 8 | Baník | 34 | 49 | 13 | 10 | 11 | 48 | 38 | 10 |
| 9 | Olomouc | 34 | 45 | 11 | 12 | 11 | 40 | 40 | 0 |
| 10 | Bohemians | 34 | 43 | 10 | 13 | 11 | 40 | 37 | 3 |
| 11 | Mladá | 34 | 39 | 10 | 9 | 15 | 49 | 54 | -5 |
| 12 | Karviná | 34 | 39 | 9 | 12 | 13 | 37 | 49 | -12 |
| 13 | České B. | 34 | 38 | 9 | 11 | 14 | 33 | 47 | -14 |
| 14 | Zlín | 34 | 32 | 8 | 8 | 18 | 30 | 50 | -20 |
| 15 | Teplice | 34 | 30 | 7 | 9 | 18 | 34 | 66 | -32 |
| 16 | Brno | 34 | 26 | 5 | 11 | 18 | 33 | 57 | -24 |
| 17 | Příbram | 34 | 25 | 5 | 10 | 19 | 26 | 65 | -39 |
| 18 | Opava | 34 | 17 | 3 | 8 | 23 | 23 | 71 | -48 |
Clasificación local
Equipo | PJ | Pts | G | E | P | GA | GE | GA-GE | |
| 1 | Slavia | 17 | 47 | 15 | 2 | 0 | 45 | 9 | 36 |
| 2 | Jablonec | 17 | 41 | 13 | 2 | 2 | 34 | 16 | 18 |
| 3 | Sparta | 17 | 40 | 13 | 1 | 3 | 46 | 21 | 25 |
| 4 | V.Plzeň | 17 | 38 | 12 | 2 | 3 | 39 | 15 | 24 |
| 5 | Slovácko | 17 | 31 | 9 | 4 | 4 | 30 | 14 | 16 |
| 6 | Pardubice | 17 | 30 | 8 | 6 | 3 | 26 | 18 | 8 |
| 7 | Baník | 17 | 30 | 8 | 6 | 3 | 28 | 15 | 13 |
| 8 | Bohemians | 17 | 28 | 7 | 7 | 3 | 23 | 14 | 9 |
| 9 | Liberec | 17 | 28 | 7 | 7 | 3 | 27 | 15 | 12 |
| 10 | Olomouc | 17 | 20 | 5 | 5 | 7 | 20 | 20 | 0 |
| 11 | Mladá | 17 | 20 | 5 | 5 | 7 | 27 | 28 | -1 |
| 12 | České B. | 17 | 19 | 5 | 4 | 8 | 14 | 24 | -10 |
| 13 | Karviná | 17 | 18 | 4 | 6 | 7 | 18 | 23 | -5 |
| 14 | Teplice | 17 | 18 | 4 | 6 | 7 | 17 | 24 | -7 |
| 15 | Zlín | 17 | 16 | 4 | 4 | 9 | 17 | 28 | -11 |
| 16 | Příbram | 17 | 13 | 3 | 4 | 10 | 13 | 31 | -18 |
| 17 | Brno | 17 | 11 | 2 | 5 | 10 | 15 | 28 | -13 |
| 18 | Opava | 17 | 11 | 2 | 5 | 10 | 11 | 29 | -18 |
Clasificación visita
Equipo | PJ | Pts | G | E | P | GA | GE | GA-GE | |
| 1 | Slavia | 17 | 39 | 11 | 6 | 0 | 40 | 11 | 29 |
| 2 | Sparta | 17 | 34 | 10 | 4 | 3 | 36 | 22 | 14 |
| 3 | Slovácko | 17 | 32 | 10 | 2 | 5 | 28 | 19 | 9 |
| 4 | Jablonec | 17 | 28 | 8 | 4 | 5 | 25 | 17 | 8 |
| 5 | Olomouc | 17 | 25 | 6 | 7 | 4 | 20 | 20 | 0 |
| 6 | Liberec | 17 | 24 | 7 | 3 | 7 | 17 | 17 | 0 |
| 7 | Pardubice | 17 | 22 | 7 | 1 | 9 | 15 | 24 | -9 |
| 8 | Karviná | 17 | 21 | 5 | 6 | 6 | 19 | 26 | -7 |
| 9 | V.Plzeň | 17 | 20 | 5 | 5 | 7 | 21 | 30 | -9 |
| 10 | České B. | 17 | 19 | 4 | 7 | 6 | 19 | 23 | -4 |
| 11 | Mladá | 17 | 19 | 5 | 4 | 8 | 22 | 26 | -4 |
| 12 | Baník | 17 | 19 | 5 | 4 | 8 | 20 | 23 | -3 |
| 13 | Zlín | 17 | 16 | 4 | 4 | 9 | 13 | 22 | -9 |
| 14 | Brno | 17 | 15 | 3 | 6 | 8 | 18 | 29 | -11 |
| 15 | Bohemians | 17 | 15 | 3 | 6 | 8 | 17 | 23 | -6 |
| 16 | Teplice | 17 | 12 | 3 | 3 | 11 | 17 | 42 | -25 |
| 17 | Příbram | 17 | 12 | 2 | 6 | 9 | 13 | 34 | -21 |
| 18 | Opava | 17 | 6 | 1 | 3 | 13 | 12 | 42 | -30 |