USL Championship | 19-Mar-22 20:00 | 19Mar | Western Conference | LA Gal II | 1:2 | SAFC | |
| 19-Mar-22 20:00 | 19Mar | Western Conference | Clrdo Spr | 1:0 | Monterey | |
| 19-Mar-22 20:00 | 19Mar | Western Conference | El Paso L | 1:2 | New Mexic | |
| 19-Mar-22 20:00 | 19Mar | Western Conference | SD Loyal | 2:0 | Sac Repub | |
| 19-Mar-22 20:00 | 19Mar | Western Conference | OC SC | 2:1 | RGVFC | |
| 19-Mar-22 20:00 | 19Mar | Western Conference | Las Vegas | 2:1 | Phoenix R | |
| 19-Mar-22 20:00 | 19Mar | Inter-Conference | Detroit | 2:1 | Oakland | |
| 19-Mar-22 19:30 | 19Mar | Eastern Conference | Tulsa | 3:1 | Legion | |
| 19-Mar-22 18:30 | 19Mar | Eastern Conference | Pttsburgh | 2:1 | Hartford | |
| 19-Mar-22 18:30 | 19Mar | Eastern Conference | Louisvill | 2:0 | Miami FC | |
| 19-Mar-22 18:30 | 19Mar | Eastern Conference | Tampa Bay | 2:0 | Indy XI | |
| 19-Mar-22 15:00 | 19Mar | Eastern Conference | Detroit | 1:0 | Charlston | |
| 19-Mar-22 12:00 | 19Mar | Eastern Conference | NY RB II | 0:3 | Loudoun | |
| 13-Mar-22 16:00 | 13Mar | Western Conference | New Mexic | 2:0 | Las Vegas | Flores, G |
| 13-Mar-22 15:00 | 13Mar | Eastern Conference | Legion | 1:1 | Tampa Bay | Thompson, M |
| 12-Mar-22 20:00 | 12Mar | Western Conference | SD Loyal | 2:1 | LA Gal II | Arreguin |
| 12-Mar-22 20:00 | 12Mar | Western Conference | Sac Repub | 3:1 | El Paso L | Garcia, E |
| 12-Mar-22 19:30 | 12Mar | Western Conference | Phoenix R | 4:2 | Monterey | Radosav |
| 12-Mar-22 19:30 | 12Mar | Inter-Conference | SAFC | 1:0 | Detroit | Osmanovic |
| 12-Mar-22 18:30 | 12Mar | Eastern Conference | Louisvill | 1:0 | Atlanta 2 | Rivas, M |
| 12-Mar-22 18:00 | 12Mar | Eastern Conference | Memphis | 0:3 | Pttsburgh | Broadley |
| 12-Mar-22 18:00 | 12Mar | Eastern Conference | Miami FC | 2:0 | NY RB II | Giusti |
| 12-Mar-22 18:00 | 12Mar | Eastern Conference | Charlston | 1:0 | Tulsa | Encarnación, J |
| 12-Mar-22 17:30 | 12Mar | Western Conference | RGVFC | 1:0 | Oakland | Stevis |
| 12-Mar-22 17:00 | 12Mar | Eastern Conference | Loudoun | 1:0 | Indy XI | Matto |
| 12-Mar-22 17:00 | 12Mar | Western Conference | Clrdo Spr | 2:1 | OC SC | Alael-din Badawi |