| Austin FC | 1 : 0 | LAFC | gol: Wolff |
| Seattle | 1 : 1 | Columbus | gol: Rossi, Rothrock car. rosso: Kossa-Rienzi |
| Cincy | 2 : 1 | Chicago | gol: Evander, Denkey, Zinckernagel |
| DC United | 0 : 0 | Atlanta | |
| Montréal | 1 : 4 | Int Miami | gol: Owusu, Allende, Messi, Segovia. 2 assist Suárez |
| Nashville | 1 : 0 | Philly | gol: Mukhtar (rigore) car. rosso: PĂ©rez |
| Salt Lake | 3 : 2 | STL City | gol: Caliskan (autorete + 1), Diogo Gonçalves, Klauss (testa), Yaro (autorete) |
| Portland | 2 : 1 | N England | gol: Smith, Langoni, David Costa |
| San Diego | 3 : 4 | Houston | gol: Iloski, Ennali, Escobar, Bombino, Valakari, Ponce (rigore + 1). 2 assist Bartlow |
| San Jose | 1 : 1 | NY RB | gol: Forsberg, Sofo (autorete) car. rosso: Jones |
| Charlotte | 2 : 2 | Orlando | gol: Pep Biel, Tuiloma (testa), Enrique, Pašalić |
| FC Dallas | 1 : 2 | MN Utd | gol: Harvey (testa), Markanich (testa), Farrington |
| Colorado | 1 : 2 | Sprtng KC | gol: Joveljić, Thommy, Rafael Navarro (rigore) |
| LA Galaxy | 3 : 0 | Whitecaps | gol: Matheus Nascimento, Paintsil (rigore + 1) car. rosso: Nelson |
| NY City | 3 : 1 | Toronto | gol: Wolf, IleniÄŤ, Romero (autorete), O'Toole |
