Giornata
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| Orlando | 1 : 2 | NY City | gol: Jansson, Smith (autorete), Martínez |
| Atlanta | 2 : 2 | Chicago | gol: Zinckernagel (punizione), Miranchuk, Haile-Selassie, Reilly |
| Charlotte | 2 : 1 | DC United | gol: Pep Biel, Gabriel Pirani |
| Cincy | 3 : 0 | Int Miami | gol: Valenzuela, Evander |
| NY RB | 5 : 3 | N England | gol: Campana, Duncan (autorete), Edelman, Choupo-Moting, Forsberg (rigore + 1). 2 assist Donkor |
| Philly | 2 : 1 | Montréal | gol: Baribo, Owusu, Makhanya (testa) |
| Houston | 0 : 3 | Whitecaps | gol: Sabbi, Berhalter, White rigore sbagliato + 1) |
| MN Utd | 0 : 1 | LAFC | gol: Bouanga (rigore) |
| Nashville | 3 : 0 | Columbus | gol: Zawadzki (autorete), Mukhtar, Surridge |
| LA Galaxy | 1 : 2 | Austin FC | gol: Uzuni, Wolff, Paintsil (rigore) |
| Portland | 0 : 1 | Salt Lake | gol: Diogo Gonçalves |
| San Diego | 0 : 1 | Toronto | gol: Corbeanu (rigore) |
| San Jose | 2 : 2 | FC Dallas | gol: Harkes, Musa, Martinez (testa) |
| Seattle | 3 : 3 | Colorado | gol: Vargas, Rusnák, Mihailovic (rigore), Bassett (rigore), Yapi |
