| Ch.Odesa | 0 : 1 | Ludogrets | goals: Zlatinski (free kick) |
| Shakhter | 1 : 1 | AZ | goals: Finonchenko, GuĂ°mundsson |
| Valencia | 5 : 1 | St Gallen | goals: Alcácer, Cartabia, Ricardo Costa (head), Canales (free kick), Nater |
| Dinamo Zg | 0 : 0 | PSV | |
| Elfsborg | 1 : 2 | Esbjerg | goals: Andreasen (2 head), Jönsson (free kick) |
| Salzburg | 2 : 1 | Standard | goals: Soriano, André Ramalho, Mujangi Bia (penalty) red car: Mané, Kanu, Carcela Gonzalez |
| Z Waregem | 1 : 3 | Maribor | goals: De Fauw, CrniÄŤ, Mertelj, Mezga red car: Milec |
| Fiorentina | 3 : 0 | Pandurii | goals: JoaquĂn, Ryder Matos, Cuadrado |
| Bordeaux | 2 : 1 | APOEL | goals: Sané (head), Gonçalves, Henrique (head) |
| Frankfurt | 2 : 0 | M TelAviv | goals: Kadlec, Meier (head) red car: Ben Haim |
| Swansea | 1 : 1 | Kuban | |
| Wigan | 1 : 1 | Rubin | goals: Prudnikov, Powell |
| Paços | 0 : 2 | Dnipro | goals: Rotan, Konoplyanka |
| D.Kyiv | 3 : 0 | Thun | goals: Yarmolenko, Mbokani (head), Husyev. 2 assists Danilo Silva |
| Trabzon | 2 : 0 | Legia | goals: Janko, Adin (free kick) |
| Apollon | 0 : 0 | Lazio | |
| Anzhi | 1 : 0 | Tromsø | goals: Burmistrov |
| Sheriff | 0 : 2 | Tottenham | goals: Vertonghen (head), Defoe |
| PAOK | 3 : 2 | M Haifa | goals: Ndlovu, Golasa, Miguel VĂtor (head), Stoch miss penalty), Ninis (head), Salpingidis. 2 assists Lino |
| Genk | 1 : 1 | SK Rapid | goals: Gorius, Sabitzer (head) |
| Liberec | 1 : 1 | Sevilla | goals: Rabušic, Vitolo red car: Kovář |
| Freiburg | 1 : 1 | Estoril | goals: Darida, Sebá |
| Lyon | 1 : 0 | Rijeka | goals: Grenier (head) |
| Betis | 1 : 0 | Guimaraes | goals: Vadillo |
