| Molde | 2 : 1 | UCD | goals: Gussiås, Østigård, Ryan -- AET -- -- Penalty shoot-out -- |
| Vllaznia | 2 : 4 | Zimbru | goals: Dontu, Pusi, Furtună (own goal), Stînă, Scoarţă, Iurasco |
| Iberia | 1 : 1 | Bursa | goals: Yılmaz, Tabatadze |
| Željez | 3 : 2 | Ludogrets | goals: Dacić, Klimentov (free kick), Mujagić, Milkov, Hajdarević |
| Honvéd | 1 : 0 | Sutjeska | goals: Májer red car: Babić |
| Sparta | 3 : 1 | Dudelange | goals: Omosanya, Maksic, Fisl (head), Flak. 2 assists Frýdek |
| M Haifa | 0 : 1 | Brodarac | goals: Babović |
| Benfica | 2 : 2 | Man.Utd | goals: Nuno Santos, Zé Gomes, Bohui (penalty + 1). 2 assists Jota red car: Boonen |
| Bayern | 6 : 2 | Celtic | goals: Evina, Götze, Deas (own goal), Johnston, Henderson, Pudić, Wintzheimer (head + 1). 2 assists Batista-Meier |
| Barcelona | 5 : 0 | Olympiacs | goals: Carles Pérez, Monchu (free kick), Kike Saverio, Puig. 2 assists Puig red car: Lamprou |
| Krasnodar | 9 : 0 | Kairat | goals: Utkin, Suleymanov, Ignatyev (penalty + 4), Kurazhov. 3 assists Utkin. 2 assists Suleymanov |
| Anderlcht | 0 : 2 | PSG | goals: Güclü, Bernede |
| Juventus | 1 : 4 | Sporting | goals: Rafael Leão, Miguel Luís (penalty), Cabral, Capellini red car: Cabral |
| NK Loko | 2 : 2 | Dinamo | goals: Vasile (penalty), Krajinović, Cretu (free kick), Vranjković red car: Gheorghe |
| Chelsea | 0 : 2 | Roma | goals: Marcucci (penalty), Valeau |
| Esbjerg | 2 : 1 | KäPa | goals: Møller, Egelund, Kiuru |
| CSKA | 2 : 3 | Basel | goals: Zhironkin (head), Vesco, Schmid, Zakharov, Pululu. 2 assists Okafor |
| D.Kyiv | 0 : 3 | Inter | goals: Pinamonti, Odgaard. 2 assists Rada |
| Qarabağ | 1 : 5 | A. Madrid | goals: Carlos Isaac, Deda, Moya, Aitor Puñal, Salido. 2 assists Moya |
| Ajax | 2 : 0 | Hammarby | goals: Ylätupa, Nunnely |
| R. Madrid | 1 : 1 | Tottenham | goals: Roles, Dani Gómez |
| Legia | 0 : 0 | Breidablk | |
| Salzburg | 4 : 0 | Bordeaux | goals: Meisl, Meisl, Gazibegović, Schmidt. 2 assists Szoboszlai |
| Shakhtyor | 3 : 0 | Liepaja | goals: Tsevan, Kutsepalov, Bal |
| Man.City | 3 : 1 | Napoli | goals: Díaz (penalty + 1), Russo, Garré |
| Monaco | 3 : 0 | Beşiktaş | goals: Abanda, Mboula |
| Feyenoord | 4 : 0 | Shakhtar | goals: Kökçü, Zwarts, Vente. 2 assists El Bouchataoui |
| Leipzig | 0 : 2 | Porto | goals: Dalot, Romário Baró |
| APOEL | 0 : 2 | Dortmund | goals: Bruun Larsen, Sancho |
| Shkendija | 1 : 1 | Nitra | goals: Chobot, Rasimi |
| Maribor | 1 : 4 | Liverpool | goals: Matko, Adekanye, Kane, Millar red car: Hodžić |
| Spartak M | 1 : 1 | Sevilla | goals: Josema (head), Rudenko red car: Petrunin, Kalachevskiy |
