AFC Champions League 
| 14-Apr-21 19:00 | 14Apr | Group B | Pakhtakor | 3:3 | Tractor | Iida |
| 14-Apr-21 20:00 | 14Apr | Group E | Perspolis | 1:0 | Wahda | Kimura |
| 14-Apr-21 21:00 | 14Apr | Group D | Al-Wehdat | 0:0 | Al-Nassr | Mazaroua |
| 14-Apr-21 21:00 | 14Apr | Group D | Al-Sadd | 1:1 | Foolad | Tufaylieh |
| 14-Apr-21 22:00 | 14Apr | Group B | Sharjah | 1:0 | Al-Quwa | Shukralla |
| 14-Apr-21 22:30 | 14Apr | Group E | Goa | 0:0 | Al-Rayyan | Nasaruddin |
| 15-Apr-21 20:45 | 15Apr | Group C | Al-Duhail | 2:0 | Al Shorta | Taqi |
| 15-Apr-21 22:00 | 15Apr | Group A | Istiklol | 0:0 | Shabab AE | Perera |
| 15-Apr-21 22:00 | 15Apr | Group A | Al-Hilal | 2:2 | AGMK | Sato |
| 15-Apr-21 23:15 | 15Apr | Group C | Esteghlal | 5:2 | AhliSaudi | Al-Ali, Ahmed |
| 17-Apr-21 19:00 | 17Apr | Group B | Al-Quwa | 0:0 | Pakhtakor | Abo Yehia |
| 17-Apr-21 20:00 | 17Apr | Group E | Wahda | 0:0 | Goa | Al-Alili |
| 17-Apr-21 21:00 | 17Apr | Group D | Al-Nassr | 3:1 | Al-Sadd | Ali, SA |
| 17-Apr-21 21:00 | 17Apr | Group D | Foolad | 1:0 | Al-Wehdat | Shaban |
| 17-Apr-21 22:00 | 17Apr | Group B | Tractor | 0:0 | Sharjah | Ma Ning |
| 17-Apr-21 22:30 | 17Apr | Group E | Al-Rayyan | 1:3 | Perspolis | Tantashev |
| 18-Apr-21 20:45 | 18Apr | Group C | AhliSaudi | 1:1 | Al-Duhail | Pu-Udom |
| 18-Apr-21 22:00 | 18Apr | Group A | Shabab AE | 0:2 | Al-Hilal | Mohanad |
| 18-Apr-21 22:00 | 18Apr | Group A | AGMK | 2:3 | Istiklol | Amirul Izwan |
| 18-Apr-21 23:15 | 18Apr | Group C | Al Shorta | 0:3 | Esteghlal | Robesh |
| 20-Apr-21 19:00 | 20Apr | Group B | Al-Quwa | 0:0 | Tractor | Al Kaf |
| 20-Apr-21 20:00 | 20Apr | Group E | Wahda | 3:2 | Al-Rayyan | Nasaruddin |
| 20-Apr-21 21:00 | 20Apr | Group D | Al-Sadd | 3:1 | Al-Wehdat | Perera |
| 20-Apr-21 21:00 | 20Apr | Group D | Foolad | 1:1 | Al-Nassr | Sato |
| 20-Apr-21 22:00 | 20Apr | Group B | Sharjah | 4:1 | Pakhtakor | Iida |
| 20-Apr-21 22:30 | 20Apr | Group E | Perspolis | 2:1 | Goa | Hattab |
| 21-Apr-21 20:45 | 21Apr | Group C | Al-Duhail | 4:3 | Esteghlal | Al-Ali, Ahmed |
| 21-Apr-21 22:00 | 21Apr | Group A | Al-Hilal | 3:1 | Istiklol | Tufaylieh |
| 21-Apr-21 22:00 | 21Apr | Group A | AGMK | 2:1 | Shabab AE | Abdulnabi |
| 21-Apr-21 23:15 | 21Apr | Group C | Al Shorta | 0:3 | AhliSaudi | Taqi |
| 23-Apr-21 19:00 | 23Apr | Group B | Tractor | 1:0 | Al-Quwa | Iida |
| 23-Apr-21 20:00 | 23Apr | Group E | Al-Rayyan | 0:1 | Wahda | Al-Alili |
| 23-Apr-21 21:00 | 23Apr | Group D | Al-Wehdat | 0:2 | Al-Sadd | Amirul Izwan |
| 23-Apr-21 21:00 | 23Apr | Group D | Al-Nassr | 2:0 | Foolad | Mohanad |
| 23-Apr-21 22:00 | 23Apr | Group B | Pakhtakor | 1:1 | Sharjah | Ma Ning |
| 23-Apr-21 22:30 | 23Apr | Group E | Goa | 0:4 | Perspolis | Kimura |
| 24-Apr-21 20:45 | 24Apr | Group C | AhliSaudi | 2:1 | Al Shorta | Pu-Udom |
| 24-Apr-21 22:00 | 24Apr | Group A | Istiklol | 4:1 | Al-Hilal | Mazaroua |
| 24-Apr-21 22:00 | 24Apr | Group A | Shabab AE | 3:1 | AGMK | Ali, SA |
| 24-Apr-21 23:15 | 24Apr | Group C | Esteghlal | 2:2 | Al-Duhail | Taqi |
| 26-Apr-21 19:00 | 26Apr | Group B | Tractor | 0:0 | Pakhtakor | Abo Yehia |
| 26-Apr-21 20:00 | 26Apr | Group E | Wahda | 1:0 | Perspolis | Tantashev |
| 26-Apr-21 21:00 | 26Apr | Group D | Al-Nassr | 1:2 | Al-Wehdat | Abdulnabi |
| 26-Apr-21 21:00 | 26Apr | Group D | Foolad | 0:1 | Al-Sadd | Shaban |
| 26-Apr-21 22:00 | 26Apr | Group B | Al-Quwa | 2:3 | Sharjah | Al Kaf |
| 26-Apr-21 22:30 | 26Apr | Group E | Al-Rayyan | 1:1 | Goa | Hattab |
| 27-Apr-21 20:45 | 27Apr | Group C | Al Shorta | 2:1 | Al-Duhail | Mazaroua |
| 27-Apr-21 22:00 | 27Apr | Group A | Shabab AE | 0:1 | Istiklol | Amirul Izwan |
| 27-Apr-21 22:00 | 27Apr | Group A | AGMK | 0:3 | Al-Hilal | Perera |
| 27-Apr-21 23:15 | 27Apr | Group C | AhliSaudi | 0:0 | Esteghlal | Sato |
| 29-Apr-21 19:00 | 29Apr | Group B | Pakhtakor | 1:0 | Al-Quwa | Shukralla |
| 29-Apr-21 20:00 | 29Apr | Group E | Perspolis | 4:2 | Al-Rayyan | Kimura |
| 29-Apr-21 21:00 | 29Apr | Group D | Al-Sadd | 1:2 | Al-Nassr | Tufaylieh |
| 29-Apr-21 21:00 | 29Apr | Group D | Al-Wehdat | 1:0 | Foolad | Ali, SA |
| 29-Apr-21 22:00 | 29Apr | Group B | Sharjah | 0:2 | Tractor | Iida |
| 29-Apr-21 22:30 | 29Apr | Group E | Goa | 0:2 | Wahda | Mahfoodh |
| 30-Apr-21 20:45 | 30Apr | Group C | Esteghlal | 1:0 | Al Shorta | Pu-Udom |
| 30-Apr-21 22:00 | 30Apr | Group A | Al-Hilal | 0:2 | Shabab AE | Abdulnabi |
| 30-Apr-21 22:00 | 30Apr | Group A | Istiklol | 1:2 | AGMK | Mohanad |
| 30-Apr-21 23:15 | 30Apr | Group C | Al-Duhail | 1:1 | AhliSaudi | Perera |
| 22-Jun-21 17:00 | 22Jun | Group G | Pohang | 2:0 | Ratchabur | Ma Ning |
| 22-Jun-21 21:00 | 22Jun | Group G | JDT | 0:1 | Nagoya | Mohamed, M |
| 24-Jun-21 17:00 | 24Jun | Group J | GZ FC COVID | 0:2 | C Osaka | Shukralla |
| 24-Jun-21 21:00 | 24Jun | Group J | Kitchee | 2:0 | Port FC | Dae-yong Kim |
| 25-Jun-21 17:00 | 25Jun | Group G | Nagoya | 3:0 | Pohang | Al-Khudair |
| 25-Jun-21 19:00 | 25Jun | Group H | TampinesR | 0:2 | G Osaka | Robesh |
| 25-Jun-21 21:00 | 25Jun | Group G | Ratchabur | 0:1 | JDT | Faghani |
| 25-Jun-21 21:00 | 25Jun | Group H | Jeonbuk | 2:1 | Chiangrai | Al-Jassim |
| 26-Jun-21 17:00 | 26Jun | Group F | BG Pathum | 4:1 | Kaya | Sato |
| 26-Jun-21 19:00 | 26Jun | Group I | Utd City | 1:1 | Guoan COVID | Bonyadifard |
| 26-Jun-21 21:00 | 26Jun | Group F | Viettel F | 0:1 | Ulsan | Mohanad |
| 26-Jun-21 21:00 | 26Jun | Group I | Kawasaki | 3:2 | Daegu FC | Al Kaf |
| 27-Jun-21 17:00 | 27Jun | Group J | Port FC | 3:0 | GZ FC COVID | Heidari |
| 27-Jun-21 21:00 | 27Jun | Group J | C Osaka | 2:1 | Kitchee | Al-Marri |
| 28-Jun-21 17:00 | 28Jun | Group G | Ratchabur | 0:4 | Nagoya | Mazaroua |
| 28-Jun-21 19:00 | 28Jun | Group H | Chiangrai | 1:0 | TampinesR | Al-Ali, Omar |
| 28-Jun-21 21:00 | 28Jun | Group G | Pohang | 4:1 | JDT | Evans, Shaun |
| 28-Jun-21 21:00 | 28Jun | Group H | G Osaka | 2:2 | Jeonbuk | Al-Hoaish |
| 29-Jun-21 17:00 | 29Jun | Group F | Ulsan | 2:0 | BG Pathum | Al-Adba |
| 29-Jun-21 19:00 | 29Jun | Group I | Daegu FC | 7:0 | Utd City | Amirul Izwan |
| 29-Jun-21 21:00 | 29Jun | Group F | Kaya | 0:5 | Viettel F | Mahfoodh |
| 29-Jun-21 21:00 | 29Jun | Group I | Guoan COVID | 0:7 | Kawasaki | Tufaylieh |
| 30-Jun-21 17:00 | 30Jun | Group J | C Osaka | 1:1 | Port FC | Hyung-Jin Ko |
| 30-Jun-21 21:00 | 30Jun | Group J | GZ FC COVID | 0:1 | Kitchee | Shaban |
| 01-Jul-21 17:00 | 01Jul | Group G | JDT | 0:2 | Pohang | Ma Ning |
| 01-Jul-21 19:00 | 01Jul | Group H | Jeonbuk | 9:0 | TampinesR | Yaacob |
| 01-Jul-21 21:00 | 01Jul | Group G | Nagoya | 3:0 | Ratchabur | Al-Khudair |
| 01-Jul-21 21:00 | 01Jul | Group H | Chiangrai | 1:1 | G Osaka | Al Kaf |
| 02-Jul-21 17:00 | 02Jul | Group F | Kaya | 0:3 | Ulsan | Abo Yehia |
| 02-Jul-21 19:00 | 02Jul | Group I | Kawasaki | 8:0 | Utd City | Akrami |
| 02-Jul-21 19:00 | 02Jul | Group I | Daegu FC | 5:0 | Guoan COVID | Al-Hoaish |
| 02-Jul-21 21:00 | 02Jul | Group F | BG Pathum | 2:0 | Viettel F | Hattab |
| 03-Jul-21 17:00 | 03Jul | Group J | Port FC | 0:3 | C Osaka | Shukralla |
| 03-Jul-21 21:00 | 03Jul | Group J | Kitchee | 1:0 | GZ FC COVID | Al-Marri |
| 04-Jul-21 17:00 | 04Jul | Group G | Ratchabur | 0:0 | Pohang | Al-Adba |
| 04-Jul-21 19:00 | 04Jul | Group H | TampinesR | 0:4 | Jeonbuk | Tufaylieh |
| 04-Jul-21 21:00 | 04Jul | Group G | Nagoya | 2:1 | JDT | Faghani |
| 04-Jul-21 21:00 | 04Jul | Group H | G Osaka | 1:1 | Chiangrai | Amirul Izwan |
| 05-Jul-21 17:00 | 05Jul | Group F | Ulsan | 2:1 | Kaya | Mazaroua |
| 05-Jul-21 19:00 | 05Jul | Group I | Utd City | 0:2 | Kawasaki | Al-Ali, Omar |
| 05-Jul-21 19:00 | 05Jul | Group I | Guoan COVID | 0:3 | Daegu FC | Robesh |
| 05-Jul-21 21:00 | 05Jul | Group F | Viettel F | 1:3 | BG Pathum | Sato |
| 06-Jul-21 17:00 | 06Jul | Group J | C Osaka | 5:0 | GZ FC COVID | Heidari |
| 06-Jul-21 21:00 | 06Jul | Group J | Port FC | 1:1 | Kitchee | Hyung-Jin Ko |
| 07-Jul-21 17:00 | 07Jul | Group G | Pohang | 1:1 | Nagoya | Mohamed, M |
| 07-Jul-21 19:00 | 07Jul | Group H | G Osaka | 8:1 | TampinesR | Yu Ming-hsun |
| 07-Jul-21 21:00 | 07Jul | Group G | JDT | 0:0 | Ratchabur | Mohanad |
| 07-Jul-21 21:00 | 07Jul | Group H | Chiangrai | 1:3 | Jeonbuk | Bonyadifard |
| 08-Jul-21 17:00 | 08Jul | Group F | Kaya | 0:1 | BG Pathum | Mahfoodh |
| 08-Jul-21 19:00 | 08Jul | Group I | Guoan COVID | 2:3 | Utd City | Ibrahim, A |
| 08-Jul-21 21:00 | 08Jul | Group F | Ulsan | 3:0 | Viettel F | Evans, Shaun |
| 08-Jul-21 21:00 | 08Jul | Group I | Daegu FC | 1:3 | Kawasaki | Al-Jassim |
| 09-Jul-21 17:00 | 09Jul | Group J | Kitchee | 0:0 | C Osaka | Ali, SA |
| 09-Jul-21 21:00 | 09Jul | Group J | GZ FC COVID | 1:5 | Port FC | Dae-yong Kim |
| 10-Jul-21 19:00 | 10Jul | Group H | TampinesR | 0:3 | Chiangrai | Amirul Izwan |
| 10-Jul-21 19:00 | 10Jul | Group H | Jeonbuk | 2:1 | G Osaka | Al Kaf |
| 11-Jul-21 17:00 | 11Jul | Group F | Viettel F | 1:0 | Kaya | Hattab |
| 11-Jul-21 17:00 | 11Jul | Group I | Utd City | 0:4 | Daegu FC | Tantashev |
| 11-Jul-21 17:00 | 11Jul | Group I | Kawasaki | 4:0 | Guoan COVID | Al-Hoaish |
| 11-Jul-21 21:00 | 11Jul | Group F | BG Pathum | 0:2 | Ulsan | Faghani |
Matchday 7 - Round of 16 | ||||||
| 13-Sep-21 21:00 | 13Sep | Round of 16 | Esteghlal | 0:2 | Al-Hilal | Fu Ming |
| 14-Sep-21 18:00 | 14Sep | Round of 16 | Nagoya | 4:2 | Daegu FC | Makhadmeh |
| 14-Sep-21 19:00 | 14Sep | Round of 16 | Al-Nassr | 1:0 | Tractor | Dae-yong Kim |
| 14-Sep-21 20:00 | 14Sep | Round of 16 | Istiklol | 0:1 | Perspolis | Kimura |
| 14-Sep-21 20:00 | 14Sep | Round of 16 | Ulsan | 0:0 | Kawasaki | Mohamed, M |
| 14-Sep-21 21:00 | 14Sep | Round of 16 | Sharjah | 1:1 | Wahda | Shukralla |
| 15-Sep-21 17:30 | 15Sep | Round of 16 | Jeonbuk | 1:1 | BG Pathum | Bonyadifard |
| 15-Sep-21 18:00 | 15Sep | Round of 16 | C Osaka | 0:1 | Pohang | Al-Jassim |
Matchday 8 - Quarter-finals | ||||||
| 16-Oct-21 18:00 | 16Oct | Quarter-finals | Wahda | 1:5 | Al-Nassr | Ma Ning |
| 16-Oct-21 21:00 | 16Oct | Quarter-finals | Perspolis | 0:3 | Al-Hilal | Sato |
| 17-Oct-21 14:00 | 17Oct | Quarter-finals | Pohang | 3:0 | Nagoya | Faghani |
| 17-Oct-21 19:00 | 17Oct | Quarter-finals | Jeonbuk | 2:3 | Ulsan | Mohamed, M |
Matchday 9 - Semi-finals | ||||||
| 19-Oct-21 21:00 | 19Oct | Semi-finals | Al-Nassr | 1:2 | Al-Hilal | Beath |
| 20-Oct-21 19:00 | 20Oct | Semi-finals | Ulsan | 1:1 | Pohang | Al-Jassim |
Matchday 10 - Final | ||||||
| 23-Nov-21 19:00 | 23Nov | Final | Al-Hilal | 2:0 | Pohang | Mohamed, M |