CAF Champions League 
| 11-Feb-22 17:00 | 11Feb | Group C | ES Sahel | 0:0 | Belouiz | Noureddine |
| 11-Feb-22 18:00 | 11Feb | Group A | Sundowns | 1:0 | Omdurman | Bondo |
| 11-Feb-22 20:00 | 11Feb | Group D | Wydad | 3:0 | Sagrada E | Laryea |
| 12-Feb-22 14:00 | 12Feb | Group C | Espérance | 4:0 | Jwaneng | Sy |
| 12-Feb-22 16:00 | 12Feb | Group B | Horoya | 0:1 | ES Setif | Ndabihawenimana |
| 12-Feb-22 18:00 | 12Feb | Group D | Zamalek | 2:2 | Petro | Ndala |
| 12-Feb-22 20:00 | 12Feb | Group B | Raja | 1:0 | AmaZulu | Tessema |
| 18-Feb-22 15:00 | 18Feb | Group A | Omdurman | 0:0 | Al-Ahly | El Jaafari |
| 18-Feb-22 20:00 | 18Feb | Group B | ES Setif | 0:1 | Raja | NDiaye |
| 18-Feb-22 21:00 | 18Feb | Group B | AmaZulu | 1:0 | Horoya | Ngwa |
| 19-Feb-22 14:00 | 19Feb | Group D | Petro | 2:1 | Wydad | Waweru |
| 19-Feb-22 15:00 | 19Feb | Group A | Merreikh | 0:0 | Sundowns | Guirat |
| 19-Feb-22 17:00 | 19Feb | Group D | Sagrada E | 0:0 | Zamalek | Camille |
| 19-Feb-22 18:00 | 19Feb | Group C | Jwaneng | 1:1 | ES Sahel | Heeralall |
| 19-Feb-22 20:00 | 19Feb | Group C | Belouiz | 1:1 | Espérance | Adel, M |
| 25-Feb-22 18:00 | 25Feb | Group A | Merreikh | 2:1 | Omdurman | Benbraham |
| 25-Feb-22 18:00 | 25Feb | Group B | AmaZulu | 1:0 | ES Setif | Waweru |
| 25-Feb-22 20:00 | 25Feb | Group B | Raja | 1:0 | Horoya | Dahane |
| 26-Feb-22 14:00 | 26Feb | Group C | Espérance | 0:0 | ES Sahel | Gassama |
| 26-Feb-22 17:00 | 26Feb | Group D | Sagrada E | 0:1 | Petro | Mdluli |
| 26-Feb-22 18:00 | 26Feb | Group C | Jwaneng | 1:2 | Belouiz | Ngwa |
| 26-Feb-22 20:00 | 26Feb | Group D | Wydad | 3:1 | Zamalek | Selmi |
| 26-Feb-22 21:00 | 26Feb | Group A | Al-Ahly | 0:1 | Sundowns | Jiyed |
| 05-Mar-22 21:00 | 05Mar | Group A | Al-Ahly | 3:2 | Merreikh | de Carvalho |
| 11-Mar-22 15:00 | 11Mar | Group A | Omdurman | 1:0 | Merreikh | Ghorbal |
| 11-Mar-22 18:00 | 11Mar | Group D | Zamalek | 0:1 | Wydad | Ndabihawenimana |
| 11-Mar-22 20:00 | 11Mar | Group C | Belouiz | 4:1 | Jwaneng | Fadul |
| 12-Mar-22 14:00 | 12Mar | Group C | ES Sahel | 0:2 | Espérance | Maarouf |
| 12-Mar-22 15:00 | 12Mar | Group A | Sundowns | 1:0 | Al-Ahly | Tessema |
| 12-Mar-22 16:00 | 12Mar | Group B | Horoya | 2:1 | Raja | Traoré, B |
| 12-Mar-22 17:00 | 12Mar | Group D | Petro | 3:0 | Sagrada E | Sikazwe |
| 12-Mar-22 20:00 | 12Mar | Group B | ES Setif | 2:0 | AmaZulu | Guirat |
| 18-Mar-22 20:00 | 18Mar | Group A | Merreikh | 1:3 | Al-Ahly | NDiaye |
| 18-Mar-22 20:00 | 18Mar | Group B | AmaZulu | 0:2 | Raja | Bondo |
| 18-Mar-22 21:00 | 18Mar | Group B | ES Setif | 3:2 | Horoya | Srairi |
| 19-Mar-22 15:00 | 19Mar | Group D | Petro | 0:0 | Zamalek | Ngwa |
| 19-Mar-22 17:00 | 19Mar | Group A | Omdurman | 2:4 | Sundowns | Gassama |
| 19-Mar-22 20:00 | 19Mar | Group C | Jwaneng | 0:3 | Espérance | Atcho |
| 19-Mar-22 21:00 | 19Mar | Group C | Belouiz | 2:0 | ES Sahel | Jiyed |
| 19-Mar-22 21:00 | 19Mar | Group D | Sagrada E | 1:2 | Wydad | Mahmood Ismail |
| 01-Apr-22 14:00 | 01Apr | Group C | ES Sahel | 3:2 | Jwaneng | Nkounkou |
| 01-Apr-22 16:00 | 01Apr | Group B | Horoya | 1:1 | AmaZulu | Mutaz |
| 01-Apr-22 18:00 | 01Apr | Group D | Zamalek | 0:0 | Sagrada E | Alvação |
| 02-Apr-22 15:00 | 02Apr | Group A | Sundowns | 3:0 | Merreikh | Heeralall |
| 02-Apr-22 21:00 | 02Apr | Group D | Wydad | 5:1 | Petro | Benbraham |
| 02-Apr-22 22:00 | 02Apr | Group C | Espérance | 2:1 | Belouiz | Bouh |
| 03-Apr-22 21:00 | 03Apr | Group B | Raja | 1:0 | ES Setif | Omar, A |
| 03-Apr-22 22:00 | 03Apr | Group A | Al-Ahly | 1:0 | Omdurman | Sikazwe |
Matchday 7 - Quarter-finals | ||||||
| 15-Apr-22 22:00 | 15Apr | Quarter-finals | ES Setif | 0:0 | Espérance | Gomes, V |
| 16-Apr-22 17:00 | 16Apr | Quarter-finals | Petro | 2:1 | Sundowns | Sikazwe |
| 16-Apr-22 22:00 | 16Apr | Quarter-finals | Al-Ahly | 2:1 | Raja | Ndala |
| 16-Apr-22 22:00 | 16Apr | Quarter-finals | Belouiz | 0:1 | Wydad | Ndabihawenimana |
Matchday 8 - Quarter-finals | ||||||
| 22-Apr-22 22:00 | 22Apr | Quarter-finals | Raja | 1:1 | Al-Ahly | NDiaye |
| 22-Apr-22 22:00 | 22Apr | Quarter-finals | Espérance | 0:1 | ES Setif | Jiyed |
| 23-Apr-22 18:00 | 23Apr | Quarter-finals | Sundowns | 1:1 | Petro | Tessema |
| 23-Apr-22 22:00 | 23Apr | Quarter-finals | Wydad | 0:0 | Belouiz | Omar, A |
Matchday 9 - Semi-finals | ||||||
| 07-May-22 14:00 | 07May | Semi-finals | Petro | 1:3 | Wydad | Ghorbal |
| 07-May-22 21:00 | 07May | Semi-finals | Al-Ahly | 4:0 | ES Setif | Tessema |
Matchday 10 - Semi-finals | ||||||
| 13-May-22 21:00 | 13May | Semi-finals | Wydad | 1:1 | Petro | Gomes, V |
| 14-May-22 21:00 | 14May | Semi-finals | ES Setif | 2:2 | Al-Ahly | Selmi |
Matchday 11 - Final | ||||||
| 30-May-22 20:00 | 30May | Final | Al-Ahly | 0:2 | Wydad | Gomes, V |