CAF Confederation Cup 
| 13-Feb-22 14:00 | 13Feb | Group C | CotonSprt | 0:0 | Al Masry | Moussa |
| 13-Feb-22 15:00 | 13Feb | Group C | Mazembe | 1:0 | Otohô | Traoré, B |
| 13-Feb-22 16:00 | 13Feb | Group D | Simba | 3:1 | ASEC | Djama |
| 13-Feb-22 18:00 | 13Feb | Group A | Pyramids | 2:1 | AlAhli LY | Abid Charef |
| 13-Feb-22 18:00 | 13Feb | Group B | Orlando | 2:0 | JS Saoura | Mahmood Ismail |
| 13-Feb-22 20:00 | 13Feb | Group A | Sfaxien | 1:0 | Zanaco | Traore, K |
| 13-Feb-22 20:00 | 13Feb | Group D | Berkane | 5:3 | USGN | Uwikunda |
| 20-Feb-22 15:00 | 20Feb | Group A | Zanaco | 0:2 | Pyramids | Atcho |
| 20-Feb-22 16:00 | 20Feb | Group D | ASEC | 3:1 | Berkane | Sikazwe |
| 20-Feb-22 17:00 | 20Feb | Group D | USGN | 1:1 | Simba | Teklu |
| 20-Feb-22 18:00 | 20Feb | Group B | Ittihad | 3:2 | Orlando | Mahamat |
| 20-Feb-22 18:00 | 20Feb | Group C | Al Masry | 2:0 | Mazembe | Mutaz |
| 20-Feb-22 20:00 | 20Feb | Group B | JS Saoura | 2:0 | Leopards | Houngnandande |
| 20-Feb-22 21:00 | 20Feb | Group A | AlAhli LY | 2:1 | Sfaxien | Guezzaz, S |
| 23-Feb-22 14:00 | 23Feb | Group C | Otohô | 1:1 | CotonSprt | Bouh |
| 27-Feb-22 15:00 | 27Feb | Group C | Mazembe | 1:0 | CotonSprt | Djama |
| 27-Feb-22 17:00 | 27Feb | Group C | Otohô | 1:0 | Al Masry | Ouattara |
| 27-Feb-22 17:00 | 27Feb | Group D | USGN | 2:0 | ASEC | Aklassou |
| 27-Feb-22 18:00 | 27Feb | Group A | Pyramids | 1:0 | Sfaxien | Zourak |
| 27-Feb-22 18:00 | 27Feb | Group B | Ittihad | 1:1 | JS Saoura | Gueye |
| 27-Feb-22 18:00 | 27Feb | Group B | Leopards | 2:6 | Orlando | Nkounkou |
| 27-Feb-22 20:00 | 27Feb | Group D | Berkane | 2:0 | Simba | Laryea |
| 27-Feb-22 21:00 | 27Feb | Group A | AlAhli LY | 2:0 | Zanaco | Ogabor |
| 06-Mar-22 18:00 | 06Mar | Group B | Leopards | 1:2 | Ittihad | Alvação |
| 13-Mar-22 14:00 | 13Mar | Group C | CotonSprt | 2:2 | Mazembe | de Carvalho |
| 13-Mar-22 15:00 | 13Mar | Group A | Zanaco | 2:3 | AlAhli LY | Magi |
| 13-Mar-22 16:00 | 13Mar | Group D | Simba | 1:0 | Berkane | Ndala |
| 13-Mar-22 17:00 | 13Mar | Group D | ASEC | 2:1 | USGN | Camille |
| 13-Mar-22 18:00 | 13Mar | Group B | Orlando | 3:0 | Leopards | Athoumani |
| 13-Mar-22 18:00 | 13Mar | Group C | Al Masry | 1:0 | Otohô | Heeralall |
| 13-Mar-22 20:00 | 13Mar | Group A | Sfaxien | 1:1 | Pyramids | Uwikunda |
| 13-Mar-22 20:00 | 13Mar | Group B | JS Saoura | 1:0 | Ittihad | Al Banna |
| 20-Mar-22 15:00 | 20Mar | Group A | Zanaco | 1:0 | Sfaxien | Sabila |
| 20-Mar-22 15:00 | 20Mar | Group C | Al Masry | 2:0 | CotonSprt | Jayed |
| 20-Mar-22 17:00 | 20Mar | Group C | Otohô | 2:2 | Mazembe | Mahamat, A |
| 20-Mar-22 17:00 | 20Mar | Group D | USGN | 2:2 | Berkane | Al-Ghandour |
| 20-Mar-22 17:00 | 20Mar | Group D | ASEC | 3:0 | Simba | Abdulrazg |
| 20-Mar-22 18:00 | 20Mar | Group B | Ittihad | 3:2 | Leopards | Duarte |
| 20-Mar-22 20:00 | 20Mar | Group B | JS Saoura | 0:2 | Orlando | Keita, M |
| 20-Mar-22 21:00 | 20Mar | Group A | AlAhli LY | 1:0 | Pyramids | Moussa |
| 03-Apr-22 13:00 | 03Apr | Group C | Mazembe | 2:0 | Al Masry | Laryea |
| 03-Apr-22 18:00 | 03Apr | Group B | Leopards | 0:2 | JS Saoura | Milazare |
| 03-Apr-22 18:00 | 03Apr | Group B | Orlando | 0:0 | Ittihad | Uwikunda |
| 03-Apr-22 20:00 | 03Apr | Group C | CotonSprt | 0:1 | Otohô | Artan |
| 03-Apr-22 20:00 | 03Apr | Group D | Berkane | 1:0 | ASEC | Sy |
| 03-Apr-22 20:00 | 03Apr | Group D | Simba | 4:0 | USGN | de Carvalho |
| 03-Apr-22 21:00 | 03Apr | Group A | Pyramids | 1:0 | Zanaco | Attisso Attiogbe |
| 03-Apr-22 21:00 | 03Apr | Group A | Sfaxien | 0:0 | AlAhli LY | Toure |
Matchday 7 - Quarter-finals | ||||||
| 17-Apr-22 19:00 | 17Apr | Quarter-finals | Simba | 1:0 | Orlando | Guirat |
| 17-Apr-22 22:00 | 17Apr | Quarter-finals | Ittihad | 0:0 | AlAhli LY | Maarouf |
| 17-Apr-22 22:00 | 17Apr | Quarter-finals | Pyramids | 0:0 | Mazembe | Dahane |
| 17-Apr-22 22:00 | 17Apr | Quarter-finals | Al Masry | 2:1 | Berkane | Traoré, B |
Matchday 8 - Quarter-finals | ||||||
| 24-Apr-22 15:00 | 24Apr | Quarter-finals | Mazembe | 2:0 | Pyramids | Bondo |
| 24-Apr-22 18:00 | 24Apr | Quarter-finals | Orlando | 1:0 | Simba | Camille |
| 24-Apr-22 22:00 | 24Apr | Quarter-finals | AlAhli LY | 1:0 | Ittihad | Ghorbal |
| 24-Apr-22 22:00 | 24Apr | Quarter-finals | Berkane | 1:0 | Al Masry | Selmi |
Matchday 9 - Semi-finals | ||||||
| 08-May-22 15:00 | 08May | Semi-finals | Mazembe | 1:0 | Berkane | de Carvalho |
| 08-May-22 18:00 | 08May | Semi-finals | AlAhli LY | 0:2 | Orlando | Jiyed |
Matchday 10 - Semi-finals | ||||||
| 15-May-22 18:00 | 15May | Semi-finals | Orlando | 0:1 | AlAhli LY | Gassama |
| 15-May-22 22:00 | 15May | Semi-finals | Berkane | 4:1 | Mazembe | NDiaye |
Matchday 11 - Final | ||||||
| 20-May-22 20:00 | 20May | Final | Orlando | 1:1 | Berkane | Sikazwe |