Copa Libertadores 
Matchday 1 - First Stage | ||||||
| 23-Feb-21 21:30 | 23Feb | First Stage | Liverpool | 2:1 | Católica | Lamolina, N |
| 24-Feb-21 17:15 | 24Feb | First Stage | UCV | 0:0 | Caracas | Vera, M |
| 24-Feb-21 20:30 | 24Feb | First Stage | RoyalPari | 1:4 | Guaraní | Ortega, K |
Matchday 2 - First Stage | ||||||
| 02-Mar-21 19:30 | 02Mar | First Stage | Católica | 3:0 | Liverpool | Herrera |
| 03-Mar-21 18:15 | 03Mar | First Stage | Caracas | 2:0 | UCV | Vargas |
| 03-Mar-21 18:15 | 03Mar | First Stage | Guaraní | 1:1 | RoyalPari | Traci |
Matchday 3 - Second Stage | ||||||
| 09-Mar-21 19:15 | 09Mar | Second Stage | Wanderers | 1:0 | Bolivar | Garay |
| 09-Mar-21 19:15 | 09Mar | Second Stage | Santos | 2:1 | CD Lara | Matonte |
| 09-Mar-21 21:30 | 09Mar | Second Stage | Unión | 1:0 | IDV | Wilton Sampaio |
| 10-Mar-21 17:15 | 10Mar | Second Stage | Católica | 0:1 | Libertad | Arleu de Araújo |
| 10-Mar-21 20:30 | 10Mar | Second Stage | Caracas | 1:2 | Junior | Tobar |
| 10-Mar-21 21:30 | 10Mar | Second Stage | U.Chile | 1:1 | S.Lorenzo | Claus |
| 10-Mar-21 21:30 | 10Mar | Second Stage | Grêmio | 6:1 | Ayacucho | Aragón |
| 11-Mar-21 21:30 | 11Mar | Second Stage | Guaraní | 0:2 | ANacional | Valenzuela |
Matchday 4 - Second Stage | ||||||
| 16-Mar-21 18:15 | 16Mar | Second Stage | Bolivar | 5:0 | Wanderers | Guerrero, G |
| 16-Mar-21 18:15 | 16Mar | Second Stage | CD Lara | 1:1 | Santos | Carrillo |
| 16-Mar-21 19:30 | 16Mar | Second Stage | IDV | 6:2 | Unión | Roldán |
| 16-Mar-21 19:30 | 16Mar | Second Stage | Ayacucho | 1:2 | Grêmio | Ostojich |
| 17-Mar-21 19:15 | 17Mar | Second Stage | Libertad | 2:2 | Católica | Rapallini |
| 17-Mar-21 19:30 | 17Mar | Second Stage | Junior | 3:1 | Caracas | Vigliano, M |
| 17-Mar-21 21:30 | 17Mar | Second Stage | S.Lorenzo | 2:0 | U.Chile COVID | González, L |
| 18-Mar-21 19:30 | 18Mar | Second Stage | ANacional | 3:0 | Guaraní | Pitana |
Matchday 5 - Third Stage | ||||||
| 06-Apr-21 21:30 | 06Apr | Third Stage | S.Lorenzo | 1:3 | Santos | Roldán |
| 07-Apr-21 21:30 | 07Apr | Third Stage | Libertad | 1:0 | ANacional | Tello |
| 08-Apr-21 20:30 | 08Apr | Third Stage | Bolivar | 2:1 | Junior | Wilton Sampaio |
| 09-Apr-21 17:15 | 09Apr | Third Stage | IDV | 2:1 | Grêmio | Pitana |
Matchday 6 - Third Stage | ||||||
| 13-Apr-21 21:30 | 13Apr | Third Stage | Santos | 2:2 | S.Lorenzo | Ostojich |
| 14-Apr-21 19:15 | 14Apr | Third Stage | Grêmio | 1:2 | IDV | Loustau, P |
| 14-Apr-21 19:30 | 14Apr | Third Stage | ANacional | 4:1 | Libertad | Tobar |
| 15-Apr-21 19:30 | 15Apr | Third Stage | Junior | 3:0 | Bolivar | Aquino, E |
| 20-Apr-21 18:15 | 20Apr | Group B | Táchira | 3:2 | Olimpia | Ostojich |
| 20-Apr-21 18:15 | 20Apr | Group B | Al. Ready | 2:0 | Inter | Gallo, N |
| 20-Apr-21 19:15 | 20Apr | Group C | Santos | 0:2 | Barcelona | Matonte |
| 20-Apr-21 19:15 | 20Apr | Group F | Arg.Jrs | 2:0 | Nacional | Carrillo |
| 20-Apr-21 19:30 | 20Apr | Group E | S Cristal | 0:3 | São Paulo | Cunha |
| 20-Apr-21 21:30 | 20Apr | Group G | Vélez | 2:3 | Flamengo | Roldán |
| 21-Apr-21 18:00 | 21Apr | Group C | Strongest | 0:1 | Boca | Ospina, A |
| 21-Apr-21 18:00 | 21Apr | Group H | La Guaira | 1:1 | At.-MG | Tello |
| 21-Apr-21 19:00 | 21Apr | Group A | Universit | 2:3 | Palmeiras | Ferreyra |
| 21-Apr-21 19:00 | 21Apr | Group A | IDV | 1:1 | Def y Jus | Díaz de Vivar |
| 21-Apr-21 21:00 | 21Apr | Group E | Rentistas | 1:1 | Racing | Benitez, C |
| 21-Apr-21 21:00 | 21Apr | Group H | América C | 0:2 | Cerro | Echenique |
| 21-Apr-21 22:00 | 21Apr | Group G | La Calera | 2:2 | Liga | Vargas |
| 22-Apr-21 19:00 | 22Apr | Group D | Fluminense | 1:1 | River | Tobar |
| 22-Apr-21 19:00 | 22Apr | Group F | ANacional | 2:0 | U.C. | Herrera |
| 22-Apr-21 21:00 | 22Apr | Group D | Junior | 1:1 | Santa Fe | Valenzuela |
| 27-Apr-21 17:15 | 27Apr | Group G | Liga | 3:1 | Vélez | Haro, D |
| 27-Apr-21 19:15 | 27Apr | Group G | Flamengo | 4:1 | La Calera | Argote |
| 27-Apr-21 19:15 | 27Apr | Group H | At.-MG | 2:1 | América C | Fedorczuk |
| 27-Apr-21 21:30 | 27Apr | Group A | Palmeiras | 5:0 | IDV | Tobar |
| 27-Apr-21 21:30 | 27Apr | Group B | Inter | 4:0 | Táchira | Matonte |
| 27-Apr-21 21:30 | 27Apr | Group C | Boca | 2:0 | Santos | Valenzuela |
| 28-Apr-21 18:00 | 28Apr | Group H | Cerro | 0:0 | La Guaira | Herrera |
| 28-Apr-21 19:00 | 28Apr | Group A | Def y Jus | 3:0 | Universit | Hermosilla |
| 28-Apr-21 19:00 | 28Apr | Group D | Santa Fe | 1:2 | Fluminense | Cunha |
| 28-Apr-21 19:00 | 28Apr | Group F | Nacional | 4:4 | ANacional | Aragón |
| 28-Apr-21 21:00 | 28Apr | Group C | Barcelona | 4:0 | Strongest | López, D |
| 28-Apr-21 21:00 | 28Apr | Group D | River | 2:1 | Junior | Benitez, J |
| 28-Apr-21 22:00 | 28Apr | Group B | Olimpia | 2:1 | Al. Ready | Lamolina, N |
| 29-Apr-21 18:00 | 29Apr | Group F | U.C. | 0:2 | Arg.Jrs | Vargas |
| 29-Apr-21 19:00 | 29Apr | Group E | Racing | 2:1 | S Cristal | Arteaga |
| 29-Apr-21 21:00 | 29Apr | Group E | São Paulo | 2:0 | Rentistas | Gamboa, N |
| 04-May-21 18:15 | 04May | Group G | La Calera | 0:2 | Vélez | Ortega, K |
| 04-May-21 19:15 | 04May | Group C | Santos | 5:0 | Strongest | Garay |
| 04-May-21 19:15 | 04May | Group H | At.-MG | 4:0 | Cerro | Pitana |
| 04-May-21 19:30 | 04May | Group C | Barcelona | 1:0 | Boca | Rojas, A |
| 04-May-21 19:30 | 04May | Group G | Liga | 2:3 | Flamengo | Ostojich |
| 04-May-21 21:30 | 04May | Group A | Def y Jus | 1:2 | Palmeiras | Roldán |
| 05-May-21 17:00 | 05May | Group A | IDV | 4:0 | Universit | Cunha |
| 05-May-21 19:00 | 05May | Group E | Racing | 0:0 | São Paulo | Maza |
| 05-May-21 21:00 | 05May | Group B | Inter | 6:1 | Olimpia | Tello |
| 05-May-21 21:00 | 05May | Group E | Rentistas | 0:0 | S Cristal | Herrera, M |
| 05-May-21 22:00 | 05May | Group F | U.C. | 3:1 | Nacional | Daronco |
| 06-May-21 18:00 | 06May | Group F | ANacional | 0:2 | Arg.Jrs | Valenzuela |
| 06-May-21 19:00 | 06May | Group D | Junior | 1:1 | Fluminense | Bascuñán |
| 06-May-21 20:00 | 06May | Group D | Santa Fe | 0:0 | River | Herrera |
| 06-May-21 22:00 | 06May | Group B | Al. Ready | 2:0 | Táchira | Matonte |
| 06-May-21 22:00 | 06May | Group H | La Guaira | 0:0 | América C | Merlos |
| 11-May-21 18:15 | 11May | Group B | Táchira | 2:1 | Inter | Roldán |
| 11-May-21 18:15 | 11May | Group C | Strongest | 2:0 | Barcelona | Arteaga |
| 11-May-21 19:15 | 11May | Group C | Santos | 1:0 | Boca | Ferreyra |
| 11-May-21 19:30 | 11May | Group A | IDV | 0:1 | Palmeiras | Valenzuela |
| 11-May-21 19:30 | 11May | Group E | S Cristal | 0:2 | Racing | Ospina, A |
| 11-May-21 20:30 | 11May | Group G | La Calera | 2:2 | Flamengo | Rojas, A |
| 12-May-21 19:00 | 12May | Group D | Junior | 1:1 | River | Ostojich |
| 12-May-21 19:00 | 12May | Group E | Rentistas | 1:1 | São Paulo | Argote |
| 12-May-21 19:00 | 12May | Group F | Arg.Jrs | 0:1 | U.C. | Wilton Sampaio |
| 12-May-21 20:00 | 12May | Group H | La Guaira | 0:1 | Cerro | Tello |
| 12-May-21 21:00 | 12May | Group A | Universit | 1:1 | Def y Jus | Gallo, N |
| 12-May-21 21:00 | 12May | Group D | Fluminense | 2:1 | Santa Fe | Aquino, E |
| 12-May-21 21:00 | 12May | Group F | ANacional | 0:0 | Nacional | Haro, D |
| 13-May-21 19:00 | 13May | Group G | Vélez | 3:1 | Liga | Matonte |
| 13-May-21 19:00 | 13May | Group H | América C | 1:3 | At.-MG | Cunha |
| 13-May-21 20:00 | 13May | Group B | Al. Ready | 1:2 | Olimpia | Herrera |
| 18-May-21 18:15 | 18May | Group C | Strongest | 2:1 | Santos | Haro, D |
| 18-May-21 19:15 | 18May | Group A | Palmeiras | 3:4 | Def y Jus | Cunha |
| 18-May-21 19:15 | 18May | Group F | Nacional | 1:0 | U.C. | Claus |
| 18-May-21 19:30 | 18May | Group A | Universit | 3:2 | IDV | Maza |
| 18-May-21 21:30 | 18May | Group D | Fluminense | 1:2 | Junior | Tobar |
| 18-May-21 21:30 | 18May | Group E | São Paulo | 0:1 | Racing | Valenzuela |
| 19-May-21 17:00 | 19May | Group E | S Cristal | 2:0 | Rentistas | Congo |
| 19-May-21 19:00 | 19May | Group G | Vélez | 2:1 | La Calera | López, D |
| 19-May-21 20:00 | 19May | Group H | Cerro | 0:1 | At.-MG | Ostojich |
| 19-May-21 21:00 | 19May | Group D | River COVID | 2:1 | Santa Fe | Carrillo |
| 19-May-21 21:00 | 19May | Group G | Flamengo | 2:2 | Liga | Herrera |
| 19-May-21 22:00 | 19May | Group B | Táchira | 7:2 | Al. Ready | Ospina, A |
| 19-May-21 22:00 | 19May | Group H | América C | 3:1 | La Guaira | Herrera |
| 20-May-21 19:00 | 20May | Group F | Arg.Jrs | 1:0 | ANacional | Arleu de Araújo |
| 20-May-21 20:00 | 20May | Group B | Olimpia | 0:1 | Inter | Pitana |
| 20-May-21 21:00 | 20May | Group C | Boca | 0:0 | Barcelona | Roldán |
| 25-May-21 17:15 | 25May | Group D | Santa Fe | 0:0 | Junior | Cunha |
| 25-May-21 19:15 | 25May | Group D | River | 1:3 | Fluminense | Ostojich |
| 25-May-21 20:30 | 25May | Group H | Cerro | 1:0 | América C | Pitana |
| 25-May-21 21:30 | 25May | Group E | São Paulo | 3:0 | S Cristal | Roldán |
| 25-May-21 21:30 | 25May | Group E | Racing | 3:0 | Rentistas | Gamboa, N |
| 25-May-21 21:30 | 25May | Group H | At.-MG | 4:0 | La Guaira | Lamolina, N |
| 26-May-21 18:00 | 26May | Group B | Olimpia | 6:2 | Táchira | Haro, D |
| 26-May-21 19:00 | 26May | Group B | Inter | 0:0 | Al. Ready | Loustau, P |
| 26-May-21 19:00 | 26May | Group C | Barcelona | 3:1 | Santos | Rojas, A |
| 26-May-21 21:00 | 26May | Group C | Boca | 3:0 | Strongest | Tobar |
| 26-May-21 22:00 | 26May | Group F | U.C. | 2:0 | ANacional | Wilton Sampaio |
| 26-May-21 23:00 | 26May | Group F | Nacional | 2:0 | Arg.Jrs | Aquino, E |
| 27-May-21 19:00 | 27May | Group A | Palmeiras | 6:0 | Universit | Garay |
| 27-May-21 19:00 | 27May | Group A | Def y Jus | 1:1 | IDV | Edina Batista |
| 27-May-21 19:00 | 27May | Group G | Liga | 5:2 | La Calera | Betancur |
| 27-May-21 21:00 | 27May | Group G | Flamengo | 0:0 | Vélez | González, L |
Matchday 13 - Round of 16 | ||||||
| 13-Jul-21 18:15 | 13Jul | Round of 16 | Cerro | 0:2 | Fluminense | Tello |
| 13-Jul-21 19:15 | 13Jul | Round of 16 | Boca | 0:0 | At.-MG | Rojas, A |
| 13-Jul-21 21:30 | 13Jul | Round of 16 | São Paulo | 1:1 | Racing | Ospina, A |
| 14-Jul-21 18:15 | 14Jul | Round of 16 | U.C. | 0:1 | Palmeiras | Matonte |
| 14-Jul-21 19:15 | 14Jul | Round of 16 | Vélez | 1:0 | Barcelona | Claus |
| 14-Jul-21 21:30 | 14Jul | Round of 16 | Def y Jus | 0:1 | Flamengo | Aquino, E |
| 14-Jul-21 21:30 | 14Jul | Round of 16 | River | 1:1 | Arg.Jrs | Arleu de Araújo |
| 15-Jul-21 20:30 | 15Jul | Round of 16 | Olimpia | 0:0 | Inter | Loustau, P |
Matchday 14 - Round of 16 | ||||||
| 20-Jul-21 19:15 | 20Jul | Round of 16 | At.-MG | 0:0 | Boca | Ostojich |
| 20-Jul-21 21:30 | 20Jul | Round of 16 | Racing | 1:3 | São Paulo | Tejera, G |
| 21-Jul-21 17:15 | 21Jul | Round of 16 | Barcelona | 3:1 | Vélez | Maza |
| 21-Jul-21 19:15 | 21Jul | Round of 16 | Palmeiras | 1:0 | U.C. | Herrera |
| 21-Jul-21 21:30 | 21Jul | Round of 16 | Flamengo | 4:1 | Def y Jus | Tobar |
| 21-Jul-21 21:30 | 21Jul | Round of 16 | Arg.Jrs | 0:2 | River | Aquino, E |
| 22-Jul-21 21:30 | 22Jul | Round of 16 | Inter | 0:0 | Olimpia | Ferreyra |
| 03-Aug-21 19:15 | 03Aug | Round of 16 | Fluminense | 1:0 | Cerro | Roldán |
Matchday 15 - Quarter-finals | ||||||
| 10-Aug-21 21:30 | 10Aug | Quarter-finals | São Paulo | 1:1 | Palmeiras | Pitana |
| 11-Aug-21 18:15 | 11Aug | Quarter-finals | Olimpia | 1:4 | Flamengo | Rapallini |
| 11-Aug-21 21:30 | 11Aug | Quarter-finals | River | 0:1 | At.-MG | Valenzuela |
| 12-Aug-21 21:30 | 12Aug | Quarter-finals | Fluminense | 2:2 | Barcelona | Herrera |
Matchday 16 - Quarter-finals | ||||||
| 17-Aug-21 21:30 | 17Aug | Quarter-finals | Palmeiras | 3:0 | São Paulo | Roldán |
| 18-Aug-21 19:15 | 18Aug | Quarter-finals | Flamengo | 5:1 | Olimpia | Valenzuela |
| 18-Aug-21 21:30 | 18Aug | Quarter-finals | At.-MG | 3:0 | River | Tobar |
| 19-Aug-21 19:30 | 19Aug | Quarter-finals | Barcelona | 1:1 | Fluminense | Ostojich |
Matchday 17 - Semi-finals | ||||||
| 21-Sep-21 21:30 | 21Sep | Semi-finals | Palmeiras | 0:0 | At.-MG | Loustau, P |
| 22-Sep-21 21:30 | 22Sep | Semi-finals | Flamengo | 2:0 | Barcelona | Cunha |
Matchday 18 - Semi-finals | ||||||
| 28-Sep-21 21:30 | 28Sep | Semi-finals | At.-MG | 1:1 | Palmeiras | Roldán |
| 29-Sep-21 19:30 | 29Sep | Semi-finals | Barcelona | 0:2 | Flamengo | Tobar |
Matchday 19 - Final | ||||||
| 27-Nov-21 17:00 | 27Nov | Final | Palmeiras | 2:1 | Flamengo | Pitana |