Champions League Qualifying 
Matchday 1 - Preliminary Round | ||||||
| 22-Jun-21 20:00 | 22Jun | Preliminary Round | Folgore | 0:2 | Prishtina | Hyytiä, J |
| 22-Jun-21 20:00 | 22Jun | Preliminary Round | HB | 0:1 | Escaldes | Jaanovits |
Matchday 2 - Preliminary Round | ||||||
| 25-Jun-21 20:00 | 25Jun | Preliminary Round | Prishtina | 2:0 | Escaldes | Ladebäck |
Matchday 3 - 1st Qualifying Round | ||||||
| 06-Jul-21 18:00 | 06Jul | 1st Qualifying Round | HJK | 3:1 | Buducnost | Laforge |
| 06-Jul-21 18:00 | 06Jul | 1st Qualifying Round | Ferencvs | 3:0 | Prishtina | Munro, David |
| 06-Jul-21 18:00 | 06Jul | 1st Qualifying Round | Flora | 2:0 | Hibernian | Lukić |
| 06-Jul-21 19:00 | 06Jul | 1st Qualifying Round | Žalgiris | 3:1 | Linfield | Troleis |
| 06-Jul-21 19:30 | 06Jul | 1st Qualifying Round | Fola Esch | 2:2 | Lincoln | Ocenas, M. |
| 06-Jul-21 20:00 | 06Jul | 1st Qualifying Round | CFR Cluj | 3:1 | Borac | Kamphuis |
| 06-Jul-21 20:00 | 06Jul | 1st Qualifying Round | Shkendija | 0:1 | Mura | António Nobre |
| 07-Jul-21 18:00 | 07Jul | 1st Qualifying Round | B.Glimt | 2:3 | Legia | Xhaja |
| 07-Jul-21 18:00 | 07Jul | 1st Qualifying Round | Dinamo Tb | 1:2 | Neftçi | Fuxman |
| 07-Jul-21 18:30 | 07Jul | 1st Qualifying Round | SK Slovan | 2:0 | Shamrock | Gishamer |
| 07-Jul-21 19:00 | 07Jul | 1st Qualifying Round | Malmö | 1:0 | Riga FC | Hämäläinen |
| 07-Jul-21 19:00 | 07Jul | 1st Qualifying Round | Teuta | 0:4 | Sheriff | Kurgkheli |
| 07-Jul-21 19:00 | 07Jul | 1st Qualifying Round | M Haifa | 1:1 | Kairat | Milacic |
| 07-Jul-21 19:00 | 07Jul | 1st Qualifying Round | Ludogrets | 1:0 | Shakhtyor | Saggi |
| 07-Jul-21 20:00 | 07Jul | 1st Qualifying Round | Connahs | 2:2 | Alashkert | Dimitriou |
| 07-Jul-21 20:00 | 07Jul | 1st Qualifying Round | Dinamo Zg | 3:2 | Valur | Nuza |
Matchday 4 - 1st Qualifying Round | ||||||
| 13-Jul-21 18:00 | 13Jul | 1st Qualifying Round | Lincoln | 5:0 | Fola Esch | McNabb |
| 13-Jul-21 18:00 | 13Jul | 1st Qualifying Round | Valur | 0:2 | Dinamo Zg | Hovhannisyan |
| 13-Jul-21 18:00 | 13Jul | 1st Qualifying Round | Hibernian | 0:3 | Flora | Lukjančukas |
| 13-Jul-21 18:00 | 13Jul | 1st Qualifying Round | Riga FC | 1:1 | Malmö | Bogár |
| 13-Jul-21 19:00 | 13Jul | 1st Qualifying Round | Sheriff | 1:0 | Teuta | Moskalev |
| 13-Jul-21 20:00 | 13Jul | 1st Qualifying Round | Borac | 2:1 | CFR Cluj | Schnyder |
| 13-Jul-21 20:00 | 13Jul | 1st Qualifying Round | Mura | 5:0 | Shkendija | Bârsan |
| 13-Jul-21 20:00 | 13Jul | 1st Qualifying Round | Prishtina | 1:3 | Ferencvs | Kopriwa |
| 13-Jul-21 20:30 | 13Jul | 1st Qualifying Round | Buducnost | 0:4 | HJK | Draganov |
| 13-Jul-21 20:45 | 13Jul | 1st Qualifying Round | Linfield | 1:2 | Žalgiris | de Gabriele |
| 13-Jul-21 21:00 | 13Jul | 1st Qualifying Round | Shamrock | 2:1 | SK Slovan | Zebec |
| 13-Jul-21 21:30 | 13Jul | 1st Qualifying Round | Shakhtyor | 0:1 | Ludogrets | Kardeşler |
| 14-Jul-21 16:00 | 14Jul | 1st Qualifying Round | Kairat | 2:0 | M Haifa | Kopievsky |
| 14-Jul-21 17:00 | 14Jul | 1st Qualifying Round | Alashkert | 1:0 | Connahs | Pechanec |
| 14-Jul-21 19:00 | 14Jul | 1st Qualifying Round | Neftçi | 2:1 | Dinamo Tb | Muntean |
| 14-Jul-21 20:00 | 14Jul | 1st Qualifying Round | Legia | 2:0 | B.Glimt | Diamantopoulos |
Matchday 5 - 2nd Qualifying Round | ||||||
| 20-Jul-21 18:00 | 20Jul | 2nd Qualifying Round | Lincoln | 1:2 | CFR Cluj | Delajod |
| 20-Jul-21 19:00 | 20Jul | 2nd Qualifying Round | Alashkert | 0:1 | Sheriff | Obrenović |
| 20-Jul-21 20:00 | 20Jul | 2nd Qualifying Round | Dinamo Zg | 2:0 | Omonia | Gil |
| 20-Jul-21 20:00 | 20Jul | 2nd Qualifying Round | Ferencvs | 2:0 | Žalgiris | Kruashvili |
| 20-Jul-21 20:30 | 20Jul | 2nd Qualifying Round | R Wien | 2:1 | Sparta | Gözübüyük |
| 20-Jul-21 20:45 | 20Jul | 2nd Qualifying Round | Celtic | 1:1 | Midtjyl. | Schärer |
| 21-Jul-21 19:00 | 21Jul | 2nd Qualifying Round | Malmö | 2:1 | HJK | Balakin |
| 21-Jul-21 20:00 | 21Jul | 2nd Qualifying Round | Kairat | 2:1 | Red Star | Meler, H |
| 21-Jul-21 20:00 | 21Jul | 2nd Qualifying Round | Mura | 0:0 | Ludogrets | Osmers |
| 21-Jul-21 20:30 | 21Jul | 2nd Qualifying Round | SK Slovan | 0:0 | YB Bern | Kavanagh |
| 21-Jul-21 21:00 | 21Jul | 2nd Qualifying Round | Legia | 2:1 | Flora | Meshkov |
| 21-Jul-21 21:00 | 21Jul | 2nd Qualifying Round | PSV | 5:1 | Gsaray | Hernández |
| 21-Jul-21 22:00 | 21Jul | 2nd Qualifying Round | Olympiacs | 1:0 | Neftçi | João Pinheiro |
Matchday 6 - 2nd Qualifying Round | ||||||
| 27-Jul-21 18:00 | 27Jul | 2nd Qualifying Round | Omonia | 0:1 | Dinamo Zg | Nyberg |
| 27-Jul-21 19:00 | 27Jul | 2nd Qualifying Round | Flora | 0:1 | Legia | Papapetrou |
| 27-Jul-21 19:00 | 27Jul | 2nd Qualifying Round | HJK | 2:2 | Malmö | Attwell |
| 27-Jul-21 20:00 | 27Jul | 2nd Qualifying Round | Žalgiris | 1:3 | Ferencvs | Lambrechts |
| 28-Jul-21 19:45 | 28Jul | 2nd Qualifying Round | Midtjyl. | 2:1 | Celtic | Frankowski |
| 28-Jul-21 20:00 | 28Jul | 2nd Qualifying Round | Sheriff | 3:1 | Alashkert | Pandzic |
| 28-Jul-21 20:15 | 28Jul | 2nd Qualifying Round | YB Bern | 3:2 | SK Slovan | Peljto |
| 28-Jul-21 20:30 | 28Jul | 2nd Qualifying Round | Red Star | 5:0 | Kairat | Treimanis |
| 28-Jul-21 20:30 | 28Jul | 2nd Qualifying Round | CFR Cluj | 2:0 | Lincoln | Frid |
| 28-Jul-21 20:30 | 28Jul | 2nd Qualifying Round | Sparta | 2:0 | R Wien | Madden |
| 28-Jul-21 21:00 | 28Jul | 2nd Qualifying Round | Neftçi | 0:1 | Olympiacs | De Burgos Bengoetxea |
| 28-Jul-21 21:00 | 28Jul | 2nd Qualifying Round | Ludogrets | 3:1 | Mura | Di Bello |
| 28-Jul-21 21:00 | 28Jul | 2nd Qualifying Round | Gsaray | 1:2 | PSV | Irrati |
Matchday 7 - 3rd Qualifying Round | ||||||
| 03-Aug-21 19:00 | 03Aug | 3rd Qualifying Round | Malmö | 2:1 | Rangers | Marciniak |
| 03-Aug-21 19:00 | 03Aug | 3rd Qualifying Round | Sparta | 0:2 | Monaco | Oliver, M |
| 03-Aug-21 20:00 | 03Aug | 3rd Qualifying Round | PSV | 3:0 | Midtjyl. | Karasev |
| 03-Aug-21 20:00 | 03Aug | 3rd Qualifying Round | Genk | 1:2 | Shakhtar | Sidiropoulos |
| 03-Aug-21 21:00 | 03Aug | 3rd Qualifying Round | CFR Cluj | 1:1 | YB Bern | Makkelie |
| 03-Aug-21 21:00 | 03Aug | 3rd Qualifying Round | Red Star | 1:1 | Sheriff | Hategan |
| 03-Aug-21 22:00 | 03Aug | 3rd Qualifying Round | Olympiacs | 1:1 | Ludogrets | Madden |
| 04-Aug-21 20:00 | 04Aug | 3rd Qualifying Round | Dinamo Zg | 1:1 | Legia | Lahoz |
| 04-Aug-21 20:00 | 04Aug | 3rd Qualifying Round | Ferencvs | 2:0 | Slavia | Gil Manzano |
| 04-Aug-21 20:00 | 04Aug | 3rd Qualifying Round | Spartak M | 0:2 | Benfica | Jovanović |
Matchday 8 - 3rd Qualifying Round | ||||||
| 10-Aug-21 19:00 | 10Aug | 3rd Qualifying Round | Slavia | 1:0 | Ferencvs | Stieler |
| 10-Aug-21 19:45 | 10Aug | 3rd Qualifying Round | Midtjyl. | 0:1 | PSV | Turpin |
| 10-Aug-21 20:00 | 10Aug | 3rd Qualifying Round | Sheriff | 1:0 | Red Star | Zwayer |
| 10-Aug-21 20:00 | 10Aug | 3rd Qualifying Round | Rangers | 1:2 | Malmö | Vinčić |
| 10-Aug-21 20:00 | 10Aug | 3rd Qualifying Round | Benfica | 1:0 | Spartak M | Taylor, A |
| 10-Aug-21 20:00 | 10Aug | 3rd Qualifying Round | Monaco | 3:1 | Sparta | Orsato |
| 10-Aug-21 20:30 | 10Aug | 3rd Qualifying Round | YB Bern | 3:1 | CFR Cluj | Çakır |
| 10-Aug-21 20:30 | 10Aug | 3rd Qualifying Round | Shakhtar | 2:1 | Genk | Bastien |
| 10-Aug-21 21:00 | 10Aug | 3rd Qualifying Round | Legia | 0:1 | Dinamo Zg | Kovacs, I |
| 10-Aug-21 21:00 | 10Aug | 3rd Qualifying Round | Ludogrets | 2:2 | Olympiacs | Greenfield |
Matchday 9 - Play-off Round | ||||||
| 17-Aug-21 21:00 | 17Aug | Play-off Round | Salzburg | 2:1 | Brøndby | Marciniak |
| 17-Aug-21 21:00 | 17Aug | Play-off Round | Monaco | 0:1 | Shakhtar | Makkelie |
| 17-Aug-21 22:00 | 17Aug | Play-off Round | Sheriff | 3:0 | Dinamo Zg | Çakır |
| 18-Aug-21 20:00 | 18Aug | Play-off Round | Benfica | 2:1 | PSV | Brych |
| 18-Aug-21 21:00 | 18Aug | Play-off Round | YB Bern | 3:2 | Ferencvs | Collum |
| 18-Aug-21 21:00 | 18Aug | Play-off Round | Malmö | 2:0 | Ludogrets | Lahoz |
Matchday 10 - Play-off Round | ||||||
| 24-Aug-21 21:00 | 24Aug | Play-off Round | Ferencvs | 2:3 | YB Bern | Karasev |
| 24-Aug-21 21:00 | 24Aug | Play-off Round | PSV | 0:0 | Benfica | Vinčić |
| 24-Aug-21 22:00 | 24Aug | Play-off Round | Ludogrets | 2:1 | Malmö | Turpin |
| 25-Aug-21 21:00 | 25Aug | Play-off Round | Brøndby | 1:2 | Salzburg | del Cerro |
| 25-Aug-21 21:00 | 25Aug | Play-off Round | Dinamo Zg | 0:0 | Sheriff | Orsato |
| 25-Aug-21 22:00 | 25Aug | Play-off Round | Shakhtar | 2:2 | Monaco | Taylor, A |