Europa Conference League 
| 14-Sep-21 16:30 | 14Sep | Group E | M Haifa | 0:0 | Feyenoord | Maresca |
| 14-Sep-21 17:30 | 14Sep | Group A | M TelAviv | 4:1 | Alashkert | Eskås |
| 16-Sep-21 18:45 | 16Sep | Group E | Slavia | 3:1 | U Berlin | Fábio Veríssimo |
| 16-Sep-21 18:45 | 16Sep | Group F | SK Slovan | 1:3 | FC Cph. | Fabbri |
| 16-Sep-21 18:45 | 16Sep | Group F | Lincoln | 0:2 | PAOK | Harvey |
| 16-Sep-21 18:45 | 16Sep | Group G | Rennes | 2:2 | Tottenham | Özkahya |
| 16-Sep-21 18:45 | 16Sep | Group G | Mura | 0:2 | Vitesse | Al Hakim |
| 16-Sep-21 18:45 | 16Sep | Group H | Qarabağ | 0:0 | Basel | Lambrechts |
| 16-Sep-21 20:30 | 16Sep | Group H | Kairat | 0:0 | Omonia | Boyko |
| 16-Sep-21 21:00 | 16Sep | Group C | Roma | 5:1 | CSKA Sofia | Nyberg |
| 16-Sep-21 21:00 | 16Sep | Group C | B.Glimt | 3:1 | Zorya | Higler |
| 16-Sep-21 21:00 | 16Sep | Group D | Jablonec | 1:0 | CFR Cluj | Jorgji |
| 16-Sep-21 21:00 | 16Sep | Group D | Randers | 2:2 | AZ | Strukan |
| 16-Sep-21 22:00 | 16Sep | Group A | HJK | 0:2 | LASK | Levnikov, K |
| 16-Sep-21 22:00 | 16Sep | Group B | Anorthosis | 0:2 | Partizan | Kjærsgaard |
| 16-Sep-21 22:00 | 16Sep | Group B | Flora | 0:1 | KAA Gent | Farrugia Cann |
| 30-Sep-21 18:45 | 30Sep | Group A | LASK | 1:1 | M TelAviv | Balakin |
| 30-Sep-21 18:45 | 30Sep | Group B | KAA Gent | 2:0 | Anorthosis | Glova |
| 30-Sep-21 18:45 | 30Sep | Group B | Partizan | 2:0 | Flora | Weinberger |
| 30-Sep-21 18:45 | 30Sep | Group D | AZ | 1:0 | Jablonec | Obrenović |
| 30-Sep-21 19:45 | 30Sep | Group C | Zorya | 0:3 | Roma | Luís Godinho |
| 30-Sep-21 19:45 | 30Sep | Group C | CSKA Sofia | 0:0 | B.Glimt | Anufrijevs |
| 30-Sep-21 19:45 | 30Sep | Group D | CFR Cluj | 1:1 | Randers | Massa |
| 30-Sep-21 20:00 | 30Sep | Group G | Tottenham | 5:1 | Mura | Frid |
| 30-Sep-21 20:45 | 30Sep | Group A | Alashkert | 2:4 | HJK | Feșnic |
| 30-Sep-21 21:00 | 30Sep | Group E | Feyenoord | 2:1 | Slavia | Petrescu, R |
| 30-Sep-21 21:00 | 30Sep | Group E | U Berlin | 3:0 | M Haifa | Walsh |
| 30-Sep-21 21:00 | 30Sep | Group F | FC Cph. | 3:1 | Lincoln | Monzul |
| 30-Sep-21 21:00 | 30Sep | Group G | Vitesse | 1:2 | Rennes | Clancy |
| 30-Sep-21 21:00 | 30Sep | Group H | Basel | 4:2 | Kairat | Attwell |
| 30-Sep-21 22:00 | 30Sep | Group F | PAOK | 1:1 | SK Slovan | João Pinheiro |
| 30-Sep-21 22:00 | 30Sep | Group H | Omonia | 1:4 | Qarabağ | Madden |
| 21-Oct-21 17:30 | 21Oct | Group A | HJK | 0:5 | M TelAviv | Orel |
| 21-Oct-21 18:45 | 21Oct | Group C | B.Glimt | 6:1 | Roma | Palabiyik |
| 21-Oct-21 18:45 | 21Oct | Group E | M Haifa | 1:0 | Slavia | Farkas |
| 21-Oct-21 18:45 | 21Oct | Group E | Feyenoord | 3:1 | U Berlin | Kruashvili |
| 21-Oct-21 18:45 | 21Oct | Group F | FC Cph. | 1:2 | PAOK | Lambrechts |
| 21-Oct-21 18:45 | 21Oct | Group G | Mura | 1:2 | Rennes | Chinkov |
| 21-Oct-21 18:45 | 21Oct | Group G | Vitesse | 1:0 | Tottenham | Osmers |
| 21-Oct-21 19:45 | 21Oct | Group B | Anorthosis | 2:2 | Flora | Vad |
| 21-Oct-21 20:45 | 21Oct | Group A | Alashkert | 0:3 | LASK | Maae |
| 21-Oct-21 20:45 | 21Oct | Group H | Qarabağ | 2:1 | Kairat | Aranovs'kyy |
| 21-Oct-21 21:00 | 21Oct | Group B | Partizan | 0:1 | KAA Gent | Madden |
| 21-Oct-21 21:00 | 21Oct | Group D | Jablonec | 2:2 | Randers | Aghayev |
| 21-Oct-21 21:00 | 21Oct | Group F | SK Slovan | 2:0 | Lincoln | Þórarinsson, V |
| 21-Oct-21 21:00 | 21Oct | Group H | Basel | 3:1 | Omonia | Frappart |
| 21-Oct-21 22:00 | 21Oct | Group C | CSKA Sofia | 0:1 | Zorya | Schüttengruber |
| 21-Oct-21 22:00 | 21Oct | Group D | CFR Cluj | 0:1 | AZ | Özkahya |
| 04-Nov-21 17:30 | 04Nov | Group B | Flora | 2:2 | Anorthosis | Høvdanum |
| 04-Nov-21 18:45 | 04Nov | Group A | LASK | 2:0 | Alashkert | Al Hakim |
| 04-Nov-21 18:45 | 04Nov | Group B | KAA Gent | 1:1 | Partizan | Kavanagh |
| 04-Nov-21 18:45 | 04Nov | Group D | AZ | 2:0 | CFR Cluj | Durieux |
| 04-Nov-21 18:45 | 04Nov | Group D | Randers | 2:2 | Jablonec | Greenfield |
| 04-Nov-21 18:45 | 04Nov | Group F | Lincoln | 1:4 | SK Slovan | Karlsson, K |
| 04-Nov-21 19:30 | 04Nov | Group H | Kairat | 1:2 | Qarabağ | Muntean |
| 04-Nov-21 19:45 | 04Nov | Group A | M TelAviv | 3:0 | HJK | Obrenović |
| 04-Nov-21 19:45 | 04Nov | Group C | Zorya | 2:0 | CSKA Sofia | Viljanen |
| 04-Nov-21 19:45 | 04Nov | Group H | Omonia | 1:1 | Basel | Meshkov |
| 04-Nov-21 21:00 | 04Nov | Group C | Roma | 2:2 | B.Glimt | Papapetrou |
| 04-Nov-21 21:00 | 04Nov | Group E | Slavia | 1:0 | M Haifa | Steen |
| 04-Nov-21 21:00 | 04Nov | Group E | U Berlin | 1:2 | Feyenoord | Stefański |
| 04-Nov-21 21:00 | 04Nov | Group F | PAOK | 1:2 | FC Cph. | Raczkowski |
| 04-Nov-21 21:00 | 04Nov | Group G | Rennes | 1:0 | Mura | Frischer |
| 04-Nov-21 21:00 | 04Nov | Group G | Tottenham | 3:2 | Vitesse | Di Bello |
| 25-Nov-21 17:30 | 25Nov | Group B | Flora | 1:0 | Partizan | Harvey |
| 25-Nov-21 18:45 | 25Nov | Group E | M Haifa | 0:1 | U Berlin | Ocenas, M. |
| 25-Nov-21 18:45 | 25Nov | Group E | Slavia | 2:2 | Feyenoord | Gestranius |
| 25-Nov-21 18:45 | 25Nov | Group F | SK Slovan | 0:0 | PAOK | Higler |
| 25-Nov-21 18:45 | 25Nov | Group F | Lincoln | 0:4 | FC Cph. | Jónasson |
| 25-Nov-21 18:45 | 25Nov | Group G | Rennes | 3:3 | Vitesse | Eskås |
| 25-Nov-21 18:45 | 25Nov | Group G | Mura | 2:1 | Tottenham | António Nobre |
| 25-Nov-21 19:45 | 25Nov | Group A | HJK | 1:0 | Alashkert | Van Driessche |
| 25-Nov-21 21:00 | 25Nov | Group A | M TelAviv | 0:1 | LASK | Brisard |
| 25-Nov-21 21:00 | 25Nov | Group C | B.Glimt | 2:0 | CSKA Sofia | Frid |
| 25-Nov-21 21:00 | 25Nov | Group C | Roma | 4:0 | Zorya | Kovacs, I |
| 25-Nov-21 21:00 | 25Nov | Group D | Jablonec | 1:1 | AZ | Schüttengruber |
| 25-Nov-21 21:00 | 25Nov | Group D | Randers | 2:1 | CFR Cluj | Robertson |
| 25-Nov-21 21:30 | 25Nov | Group H | Kairat | 2:3 | Basel | Kikacheishvili |
| 25-Nov-21 21:45 | 25Nov | Group H | Qarabağ | 2:2 | Omonia | Krogh |
| 25-Nov-21 22:00 | 25Nov | Group B | Anorthosis | 1:0 | KAA Gent | Schnyder |
| 09-Dec-21 18:45 | 09Dec | Group A | LASK | 3:0 | HJK | Pajač |
| 09-Dec-21 18:45 | 09Dec | Group B | Partizan | 1:1 | Anorthosis | Kruashvili |
| 09-Dec-21 18:45 | 09Dec | Group B | KAA Gent | 1:0 | Flora | Sjöberg |
| 09-Dec-21 18:45 | 09Dec | Group D | AZ | 1:0 | Randers | Farrugia Cann |
| 09-Dec-21 19:45 | 09Dec | Group C | Zorya | 1:1 | B.Glimt | Jakubik |
| 09-Dec-21 19:45 | 09Dec | Group C | CSKA Sofia | 2:3 | Roma | Walsh |
| 09-Dec-21 19:45 | 09Dec | Group D | CFR Cluj | 2:0 | Jablonec | Osmers |
| 09-Dec-21 21:00 | 09Dec | Group E | Feyenoord | 2:1 | M Haifa | Balakin |
| 09-Dec-21 21:00 | 09Dec | Group E | U Berlin | 1:1 | Slavia | Obrenović |
| 09-Dec-21 21:00 | 09Dec | Group F | FC Cph. | 2:0 | SK Slovan | Vad |
| 09-Dec-21 21:00 | 09Dec | Group G | Tottenham | 0:3 | Rennes | |
| 09-Dec-21 21:00 | 09Dec | Group G | Vitesse | 3:1 | Mura | Glova |
| 09-Dec-21 21:00 | 09Dec | Group H | Basel | 3:0 | Qarabağ | Jović |
| 09-Dec-21 21:45 | 09Dec | Group A | Alashkert | 1:1 | M TelAviv | Bogár |
| 09-Dec-21 22:00 | 09Dec | Group F | PAOK | 2:0 | Lincoln | Saggi |
| 09-Dec-21 22:00 | 09Dec | Group H | Omonia | 0:0 | Kairat | Nuza |
Matchday 7 - Knockout round | ||||||
| 17-Feb-22 18:45 | 17Feb | Knockout round | PSV | 1:0 | M TelAviv | Nyberg |
| 17-Feb-22 18:45 | 17Feb | Knockout round | Midtjyl. | 1:0 | PAOK | Pawson |
| 17-Feb-22 18:45 | 17Feb | Knockout round | R Wien | 2:1 | Vitesse | Rumšas |
| 17-Feb-22 20:00 | 17Feb | Knockout round | Leicester | 4:1 | Randers | Petrescu, R |
| 17-Feb-22 20:00 | 17Feb | Knockout round | Celtic | 1:3 | B.Glimt | Treimanis |
| 17-Feb-22 20:45 | 17Feb | Knockout round | Fenerbhce | 2:3 | Slavia | Mariani |
| 17-Feb-22 21:00 | 17Feb | Knockout round | Marseille | 3:1 | Qarabağ | Dabanovic |
| 17-Feb-22 21:00 | 17Feb | Knockout round | Sparta | 0:1 | Partizan | Ekberg |
Matchday 8 - Knockout round | ||||||
| 24-Feb-22 18:45 | 24Feb | Knockout round | Randers | 1:3 | Leicester | Peljto |
| 24-Feb-22 18:45 | 24Feb | Knockout round | B.Glimt | 2:0 | Celtic | Ivanov, S |
| 24-Feb-22 18:45 | 24Feb | Knockout round | Partizan | 2:1 | Sparta | Kabakov, G |
| 24-Feb-22 19:45 | 24Feb | Knockout round | M TelAviv | 1:1 | PSV | Lechner |
| 24-Feb-22 21:00 | 24Feb | Knockout round | Slavia | 3:2 | Fenerbhce | Kavanagh |
| 24-Feb-22 21:00 | 24Feb | Knockout round | Vitesse | 2:0 | R Wien | Kehlet |
| 24-Feb-22 21:45 | 24Feb | Knockout round | Qarabağ | 0:3 | Marseille | Frankowski |
| 24-Feb-22 22:00 | 24Feb | Knockout round | PAOK | 2:1 | Midtjyl. | Visser |
Matchday 9 - Round of 16 | ||||||
| 10-Mar-22 18:45 | 10Mar | Round of 16 | Vitesse | 0:1 | Roma | Raczkowski |
| 10-Mar-22 18:45 | 10Mar | Round of 16 | Slavia | 4:1 | LASK | Treimanis |
| 10-Mar-22 18:45 | 10Mar | Round of 16 | Partizan | 2:5 | Feyenoord | Mariani |
| 10-Mar-22 19:45 | 10Mar | Round of 16 | PAOK | 1:0 | KAA Gent | Frankowski |
| 10-Mar-22 20:00 | 10Mar | Round of 16 | Leicester | 2:0 | Rennes | Greenfield |
| 10-Mar-22 21:00 | 10Mar | Round of 16 | Marseille | 2:1 | Basel | Peljto |
| 10-Mar-22 21:00 | 10Mar | Round of 16 | PSV | 4:4 | FC Cph. | Pawson |
| 10-Mar-22 21:00 | 10Mar | Round of 16 | B.Glimt | 2:1 | AZ | Dabanovic |
Matchday 10 - Round of 16 | ||||||
| 17-Mar-22 18:45 | 17Mar | Round of 16 | Basel | 1:2 | Marseille | Soares Dias |
| 17-Mar-22 18:45 | 17Mar | Round of 16 | Rennes | 2:1 | Leicester | Sidiropoulos |
| 17-Mar-22 18:45 | 17Mar | Round of 16 | FC Cph. | 0:4 | PSV | Collum |
| 17-Mar-22 18:45 | 17Mar | Round of 16 | AZ | 2:2 | B.Glimt | Kruzliak |
| 17-Mar-22 21:00 | 17Mar | Round of 16 | KAA Gent | 1:2 | PAOK | Siebert |
| 17-Mar-22 21:00 | 17Mar | Round of 16 | Roma | 1:1 | Vitesse | Petrescu, R |
| 17-Mar-22 21:00 | 17Mar | Round of 16 | LASK | 4:3 | Slavia | Visser |
| 17-Mar-22 21:00 | 17Mar | Round of 16 | Feyenoord | 3:1 | Partizan | Taylor, A |
Matchday 11 - Quarter-finals | ||||||
| 07-Apr-22 18:45 | 07Apr | Quarter-finals | Feyenoord | 3:3 | Slavia | Meler, H |
| 07-Apr-22 20:00 | 07Apr | Quarter-finals | Leicester | 0:0 | PSV | Kruzliak |
| 07-Apr-22 21:00 | 07Apr | Quarter-finals | B.Glimt | 2:1 | Roma | Gözübüyük |
| 07-Apr-22 21:00 | 07Apr | Quarter-finals | Marseille | 2:1 | PAOK | Marciniak |
Matchday 12 - Quarter-finals | ||||||
| 14-Apr-22 18:45 | 14Apr | Quarter-finals | PSV | 1:2 | Leicester | Bastien |
| 14-Apr-22 21:00 | 14Apr | Quarter-finals | Roma | 4:0 | B.Glimt | Sánchez Martínez |
| 14-Apr-22 21:00 | 14Apr | Quarter-finals | Slavia | 1:3 | Feyenoord | Aytekin |
| 14-Apr-22 22:00 | 14Apr | Quarter-finals | PAOK | 0:1 | Marseille | Makkelie |
Matchday 13 - Semi-finals | ||||||
| 28-Apr-22 20:00 | 28Apr | Semi-finals | Leicester | 1:1 | Roma | del Cerro |
| 28-Apr-22 21:00 | 28Apr | Semi-finals | Feyenoord | 3:2 | Marseille | Oliver, M |
Matchday 14 - Semi-finals | ||||||
| 05-May-22 21:00 | 05May | Semi-finals | Roma | 1:0 | Leicester | Jovanović |
| 05-May-22 21:00 | 05May | Semi-finals | Marseille | 0:0 | Feyenoord | Schärer |
Matchday 15 - Final | ||||||
| 25-May-22 21:00 | 25May | Final | Roma | 1:0 | Feyenoord | Kovacs, I |